MALT1

MALT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G7R, 3BFO, 3K0W, 3UO8, 3UOA, 3V4O, 3V55, 4I1P, 4I1R
Identifiers
Aliases	MALT1, IMD12, MLT, MLT1, PCASP1, MALT1 paracaspase
External IDs	OMIM: 604860; MGI: 2445027; HomoloGene: 4938; GeneCards: MALT1; OMA:MALT1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	58,754,477 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	65,612,138 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; tonsil; ; testicle; ; Achilles tendon; ; monocyte; ; gonad; ; lymph node; ; buccal mucosa cell; ; appendix; ; stromal cell of endometrium;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; granulocyte; ; tail of embryo; ; blood; ; subcutaneous adipose tissue; ; genital tubercle; ; neural layer of retina; ; interventricular septum; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; ubiquitin-protein transferase activity; protease binding; protein self-association; peptidase activity; protein binding; kinase activator activity; cysteine-type endopeptidase activity; hydrolase activity; identical protein binding;
Cellular component	cytoplasm; plasma membrane; nucleolus; perinuclear region of cytoplasm; nucleus; fibrillar center; cytosol; CBM complex;
Biological process	regulation of apoptotic process; defense response; regulation of T cell receptor signaling pathway; negative regulation of apoptotic process; stimulatory C-type lectin receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; proteolysis; Fc-epsilon receptor signaling pathway; T cell proliferation; B cell activation; response to fungus; positive regulation of T cell activation; positive regulation of interleukin-2 production; protein complex oligomerization; positive regulation of T cell cytokine production; positive regulation of I-kappaB kinase/NF-kappaB signaling; nuclear export; B-1 B cell differentiation; response to molecule of bacterial origin; positive regulation of protein ubiquitination; T cell receptor signaling pathway; protein ubiquitination; innate immune response; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	10892
	240354
	ENSG00000172175
	ENSMUSG00000032688
	Q9UDY8
	Q2TBA3
	NM_006785; NM_173844
	NM_172833; NM_001365019
	NP_006776; NP_776216
	NP_766421; NP_001351948
	Wikidata
View/Edit Human	View/Edit Mouse

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene.^[5]^[6]^[7] It's the human paracaspase.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172175 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032688 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, et al. (June 1999). "The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas". Blood. 93 (11): 3601–3609. doi:10.1182/blood.V93.11.3601. PMID 10339464.
^ Hosaka S, Akamatsu T, Nakamura S, Kaneko T, Kitano K, Kiyosawa K, et al. (July 1999). "Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal translocation of the t(11;18)(q21;q21) and an additional aberration of trisomy 3". The American Journal of Gastroenterology. 94 (7): 1951–1954. doi:10.1111/j.1572-0241.1999.01237.x. PMID 10406266. S2CID 188457.
^ Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, et al. (October 1999). "A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue". Oncogene. 18 (42): 5785–5794. doi:10.1038/sj.onc.1203018. PMID 10523859.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172175 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032688 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10339464-5] Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, et al. (June 1999). "The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas". Blood. 93 (11): 3601–3609. doi:10.1182/blood.V93.11.3601. PMID 10339464.

[pmid10406266-6] Hosaka S, Akamatsu T, Nakamura S, Kaneko T, Kitano K, Kiyosawa K, et al. (July 1999). "Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal translocation of the t(11;18)(q21;q21) and an additional aberration of trisomy 3". The American Journal of Gastroenterology. 94 (7): 1951–1954. doi:10.1111/j.1572-0241.1999.01237.x. PMID 10406266. S2CID 188457.

[pmid10523859-7] Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, et al. (October 1999). "A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue". Oncogene. 18 (42): 5785–5794. doi:10.1038/sj.onc.1203018. PMID 10523859.

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