MAN1B1

MAN1B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FMI, 1FO2, 1FO3, 1X9D
Identifiers
Aliases	MAN1B1, ERMAN1, MANA-ER, MRT15, ERManI, mannosidase alpha class 1B member 1
External IDs	OMIM: 604346; MGI: 2684954; HomoloGene: 5230; GeneCards: MAN1B1; OMA:MAN1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,109,189 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,242,224 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right uterine tube; ; skin of leg; ; anterior pituitary; ; apex of heart; ; skin of abdomen; ; right hemisphere of cerebellum; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; Ileal epithelium; ; spermatid; ; neural layer of retina; ; yolk sac; ; corneal stroma; ; granulocyte; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; hydrolase activity, acting on glycosyl bonds; hydrolase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; catalytic activity;
Cellular component	extracellular vesicle; integral component of membrane; Golgi apparatus; membrane; endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum quality control compartment; Golgi membrane;
Biological process	oligosaccharide metabolic process; metabolism; N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; protein alpha-1,2-demannosylation; protein glycosylation; ubiquitin-dependent ERAD pathway; trimming of terminal mannose on B branch; trimming of terminal mannose on C branch; trimming of first mannose on A branch; trimming of second mannose on A branch; endoplasmic reticulum mannose trimming;
	Sources:Amigo / QuickGO
Orthologs
	11253
	227619
	ENSG00000177239
	ENSMUSG00000036646
	Q9UKM7
	A2AJ15
	NM_016219
	NM_001029983
	NP_057303
	NP_001025154
	Wikidata
View/Edit Human	View/Edit Mouse

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177239 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036646 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW (Aug 1999). "Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis". J Biol Chem. 274 (30): 21375–86. doi:10.1074/jbc.274.30.21375. PMID 10409699.
^ Tremblay LO, Herscovics A (Nov 1999). "Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis". Glycobiology. 9 (10): 1073–8. doi:10.1093/glycob/9.10.1073. PMID 10521544.
^ "Entrez Gene: MAN1B1 mannosidase, alpha, class 1B, member 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177239 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036646 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10409699-5] Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW (Aug 1999). "Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis". J Biol Chem. 274 (30): 21375–86. doi:10.1074/jbc.274.30.21375. PMID 10409699.

[pmid10521544-6] Tremblay LO, Herscovics A (Nov 1999). "Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis". Glycobiology. 9 (10): 1073–8. doi:10.1093/glycob/9.10.1073. PMID 10521544.

[entrez-7] "Entrez Gene: MAN1B1 mannosidase, alpha, class 1B, member 1".

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