MAN2A1

MAN2A1
Identifiers
Aliases	MAN2A1, AMan II, GOLIM7, MANA2, MANII, mannosidase alpha class 2A member 1
External IDs	OMIM: 154582; MGI: 104669; HomoloGene: 1777; GeneCards: MAN2A1; OMA:MAN2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	109,869,625 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	65,062,105 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; jejunal mucosa; ; inferior ganglion of vagus nerve; ; stromal cell of endometrium; ; retinal pigment epithelium; ; endothelial cell; ; C1 segment; ; mucosa of sigmoid colon; ; duodenum;
	Top expressed in
	stroma of bone marrow; ; lacrimal gland; ; decidua; ; seminal vesicula; ; gastrula; ; vestibular membrane of cochlear duct; ; efferent ductule; ; left lobe of liver; ; Paneth cell; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	mannosidase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; hydrolase activity, acting on glycosyl bonds; metal ion binding; catalytic activity; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; hydrolase activity; carbohydrate binding; alpha-mannosidase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane; cis-Golgi network; extracellular exosome; extracellular space; Golgi medial cisterna;
Biological process	N-glycan processing; mitochondrion organization; vacuole organization; in utero embryonic development; protein deglycosylation; respiratory gaseous exchange by respiratory system; positive regulation of neurogenesis; retina morphogenesis in camera-type eye; protein glycosylation; liver development; lung alveolus development; metabolism; mannose metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4124
	17158
	ENSG00000112893
	ENSMUSG00000024085
	Q16706
	P27046
	NM_002372
	NM_008549
	NP_002363
	NP_032575
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112893 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024085 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moremen KW, Robbins PW (Dec 1991). "Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans". The Journal of Cell Biology. 115 (6): 1521–34. doi:10.1083/jcb.115.6.1521. PMC 2289207. PMID 1757461.
^ Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.
^ "Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112893 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024085 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1757461-5] Moremen KW, Robbins PW (Dec 1991). "Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans". The Journal of Cell Biology. 115 (6): 1521–34. doi:10.1083/jcb.115.6.1521. PMC 2289207. PMID 1757461.

[pmid15004235-6] Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.

[entrez-7] "Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1".

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