MAP3K10

MAP3K10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RF0
Identifiers
Aliases	MAP3K10, MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10
External IDs	OMIM: 600137; MGI: 1346879; HomoloGene: 1834; GeneCards: MAP3K10; OMA:MAP3K10 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	40,215,575 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,374,023 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; beta cell; ; nucleus accumbens; ; putamen; ; Brodmann area 9; ; right hemisphere of cerebellum;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; ventricular zone; ; neural layer of retina; ; cerebellar cortex; ; spermatocyte; ; ganglionic eminence; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein homodimerization activity; transcription corepressor activity; kinase activity; protein serine/threonine kinase activity; bHLH transcription factor binding; ATP binding; MAP kinase kinase kinase activity; JUN kinase kinase kinase activity;
Cellular component	cytoplasm; intracellular anatomical structure;
Biological process	phosphorylation; positive regulation of JUN kinase activity; cell death; positive regulation of JNK cascade; negative regulation of DNA-binding transcription factor activity; protein phosphorylation; JNK cascade; peptidyl-serine phosphorylation; protein autophosphorylation; smoothened signaling pathway; peptidyl-threonine phosphorylation; negative regulation of transcription, DNA-templated; signal transduction; apoptotic process; positive regulation of apoptotic process; MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	4294
	269881
	ENSG00000130758
	ENSMUSG00000040390
	Q02779
	Q66L42
	NM_002446
	NM_001081292; NM_001290528
	NP_002437
	NP_001277457
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040390 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
^ Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene. 10 (7): 1447–51. PMID 7731697.
^ "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040390 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8536694-5] Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.

[pmid7731697-6] Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene. 10 (7): 1447–51. PMID 7731697.

[entrez-7] "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10".

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