MAP3K12

MAP3K12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CEN, 5CEP, 5CEQ, 5CEO
Identifiers
Aliases	MAP3K12, DLK, MEKK12, MUK, ZPK, ZPKP1, mitogen-activated protein kinase kinase kinase 12, HP09298
External IDs	OMIM: 600447; MGI: 1346881; HomoloGene: 4592; GeneCards: MAP3K12; OMA:MAP3K12 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,500,063 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,425,499 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; gastric mucosa; ; right uterine tube; ; right ovary; ; right frontal lobe; ; anterior pituitary; ; canal of the cervix; ; cerebellar vermis; ; body of uterus; ; left ovary;
	Top expressed in
	ascending aorta; ; aortic valve; ; supraoptic nucleus; ; otic placode; ; submandibular gland; ; internal carotid artery; ; lobe of cerebellum; ; tunica media of zone of aorta; ; external carotid artery; ; intercostal muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein homodimerization activity; kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; protein kinase binding; protein serine/threonine kinase activity; signal transducer activity; JUN kinase kinase kinase activity;
Cellular component	cytoplasm; cytosol; membrane; growth cone; plasma membrane; axon;
Biological process	intracellular signal transduction; phosphorylation; protein phosphorylation; JNK cascade; peptidyl-serine phosphorylation; protein autophosphorylation; peptidyl-threonine phosphorylation; negative regulation of motor neuron apoptotic process; MAPK cascade; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	7786
	26404
	ENSG00000139625
	ENSMUSG00000023050
	Q12852
	Q60700
	NM_001193511; NM_006301
	NM_001163643; NM_009582; NM_001358844
	NP_001180440; NP_006292
	NP_001157115; NP_033608; NP_001345773
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023050 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reddy UR, Pleasure D (Aug 1994). "Cloning of a novel putative protein kinase having a leucine zipper domain from human brain". Biochem Biophys Res Commun. 202 (1): 613–20. doi:10.1006/bbrc.1994.1972. PMID 8037767.
^ "Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023050 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8037767-5] Reddy UR, Pleasure D (Aug 1994). "Cloning of a novel putative protein kinase having a leucine zipper domain from human brain". Biochem Biophys Res Commun. 202 (1): 613–20. doi:10.1006/bbrc.1994.1972. PMID 8037767.

[entrez-6] "Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12".

[1]

[2]

[3]

[4]

[5]

[6]