MAP3K13

MAP3K13
Identifiers
Aliases	MAP3K13, LZK, MEKK13, MLK, mitogen-activated protein kinase kinase kinase 13
External IDs	OMIM: 604915; MGI: 2444243; HomoloGene: 37958; GeneCards: MAP3K13; OMA:MAP3K13 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	185,489,094 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	21,752,189 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; caput epididymis; ; tail of epididymis; ; sperm; ; mucosa of paranasal sinus; ; lower lobe of lung; ; lactiferous duct; ; buccal mucosa cell; ; pons; ; inferior ganglion of vagus nerve;
	Top expressed in
	ureter; ; ganglionic eminence; ; neural layer of retina; ; jejunum; ; cerebellum; ; cerebellar cortex; ; colon; ; duodenum; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; identical protein binding; kinase activity; MAP kinase kinase kinase activity; protein serine/threonine kinase activity; protein kinase activity; ATP binding; protein kinase binding; metal ion binding; nucleotide binding; transferase activity; JUN kinase kinase kinase activity; IkappaB kinase complex binding; enzyme binding;
Cellular component	membrane; cytoplasm; IkappaB kinase complex;
Biological process	phosphorylation; JNK cascade; protein phosphorylation; protein autophosphorylation; positive regulation of NF-kappaB transcription factor activity; MAPK cascade; positive regulation of neuron maturation; peptidyl-serine phosphorylation; positive regulation of axon extension; positive regulation of neuron projection arborization; positive regulation of branching morphogenesis of a nerve;
	Sources:Amigo / QuickGO
Orthologs
	9175
	71751
	ENSG00000073803
	ENSMUSG00000033618
	O43283
	Q1HKZ5
	NM_001242314; NM_001242317; NM_004721
	NM_172821
	NP_001229243; NP_001229246; NP_004712
	NP_766409
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073803 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033618 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328.
^ "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073803 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033618 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9353328-5] Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328.

[entrez-6] "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13".

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