MAP3K2

MAP3K2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CU1, 2NPT, 5EX0, 5HQ8
Identifiers
Aliases	MAP3K2, MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2
External IDs	OMIM: 609487; MGI: 1346873; HomoloGene: 74576; GeneCards: MAP3K2; OMA:MAP3K2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	127,388,465 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	32,369,804 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of paranasal sinus; ; trabecular bone; ; tail of epididymis; ; caput epididymis; ; corpus epididymis; ; epithelium of nasopharynx; ; nipple; ; bronchial epithelial cell; ; pylorus;
	Top expressed in
	Rostral migratory stream; ; renal corpuscle; ; medullary collecting duct; ; ciliary body; ; iris; ; substantia nigra; ; Paneth cell; ; cumulus cell; ; fossa; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; protein kinase binding; kinase activity; ATP binding; protein serine/threonine kinase activity; transferase activity; MAP kinase kinase kinase activity; metal ion binding; protein kinase activity;
Cellular component	nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	phosphorylation; positive regulation of transcription, DNA-templated; cellular response to mechanical stimulus; protein phosphorylation; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	10746
	26405
	ENSG00000169967
	ENSMUSG00000024383
	Q9Y2U5
	Q61083
	NM_006609; NM_001371910; NM_001371911
	NM_011946
	NP_006600; NP_001358839; NP_001358840
	NP_036076
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169967 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024383 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL (Mar 1996). "Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase". The Journal of Biological Chemistry. 271 (10): 5361–8. doi:10.1074/jbc.271.10.5361. PMID 8621389.
^ Zhao Q, Lee FS (Mar 1999). "Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta". The Journal of Biological Chemistry. 274 (13): 8355–8. doi:10.1074/jbc.274.13.8355. PMID 10085062.
^ "Entrez Gene: MAP3K2 mitogen-activated protein kinase kinase kinase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169967 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024383 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8621389-5] Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL (Mar 1996). "Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase". The Journal of Biological Chemistry. 271 (10): 5361–8. doi:10.1074/jbc.271.10.5361. PMID 8621389.

[pmid10085062-6] Zhao Q, Lee FS (Mar 1999). "Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta". The Journal of Biological Chemistry. 274 (13): 8355–8. doi:10.1074/jbc.274.13.8355. PMID 10085062.

[entrez-7] "Entrez Gene: MAP3K2 mitogen-activated protein kinase kinase kinase 2".

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