MAP3K3

MAP3K3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C60, 2JRH, 2PPH, 4Y5O, 4YL6, 2O2V
Identifiers
Aliases	MAP3K3, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3
External IDs	OMIM: 602539; MGI: 1346874; HomoloGene: 69110; GeneCards: MAP3K3; OMA:MAP3K3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,622,415 bp[1] End 63,696,305 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 105,975,439 bp[2] End 106,046,272 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood gastric mucosa apex of heart right lung right coronary artery popliteal artery tibial arteries spleen Top expressed in granulocyte internal carotid artery ascending aorta aortic valve external carotid artery fossa Rostral migratory stream condyle tunica media of zone of aorta blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding protein kinase activity protein binding MAP kinase kinase kinase activity kinase activity metal ion binding nucleotide binding transferase activity protein serine/threonine kinase activity Cellular component cytosol cytoplasm Biological process intracellular signal transduction protein phosphorylation positive regulation of p38MAPK cascade protein autophosphorylation blood vessel development phosphorylation positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of mitotic cell cycle stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process MAPK cascade interleukin-1-mediated signaling pathway positive regulation of cell proliferation in bone marrow positive regulation of cell migration involved in sprouting angiogenesis negative regulation of cellular senescence signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4215 26406 Ensembl ENSG00000198909 ENSMUSG00000020700 UniProt Q99759 Q61084 RefSeq (mRNA) NM_002401 NM_203351 NM_001330431 NM_001363768 NM_011947 RefSeq (protein) NP_001317360 NP_002392 NP_976226 NP_001350697 NP_036077 Location (UCSC) Chr 17: 63.62 – 63.7 Mb Chr 11: 105.98 – 106.05 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene,^[5] which is located on the long arm of chromosome 17 (17q23.3).^[6]