MAP3K4

MAP3K4
Identifiers
Aliases	MAP3K4, MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412, mitogen-activated protein kinase kinase kinase 4
External IDs	OMIM: 602425; MGI: 1346875; HomoloGene: 31346; GeneCards: MAP3K4; OMA:MAP3K4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q26 Start 160,991,727 bp[1] End 161,117,385 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 8.42 cM|17 A1 Start 12,446,508 bp[2] End 12,537,683 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus secondary oocyte Brodmann area 23 sural nerve Achilles tendon gingival epithelium oral cavity right hemisphere of cerebellum pancreatic ductal cell right uterine tube Top expressed in fossa Rostral migratory stream condyle epithelium of lens substantia nigra medullary collecting duct facial motor nucleus vestibular membrane of cochlear duct Paneth cell primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding protein kinase activity protein binding MAP kinase kinase kinase activity kinase activity metal ion binding nucleotide binding transferase activity Cellular component perinuclear region of cytoplasm cytoplasm Biological process positive regulation of JUN kinase activity intracellular signal transduction protein phosphorylation placenta development positive regulation of telomerase activity positive regulation of p38MAPK cascade positive regulation of telomere maintenance via telomerase regulation of gene expression positive regulation of telomere capping response to UV-C phosphorylation male germ-line sex determination chorionic trophoblast cell differentiation MAPK cascade regulation of mitotic cell cycle regulation of apoptotic process signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4216 26407 Ensembl ENSG00000085511 ENSMUSG00000014426 UniProt Q9Y6R4 O08648 RefSeq (mRNA) NM_001291958 NM_001301072 NM_005922 NM_006724 NM_001363582 NM_011948 NM_001357722 RefSeq (protein) NP_001278887 NP_001288001 NP_005913 NP_006715 NP_001350511 NP_036078 NP_001344651 Location (UCSC) Chr 6: 160.99 – 161.12 Mb Chr 17: 12.45 – 12.54 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.^[5][6]

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 (p38α) and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 (p38α) and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 (MKK6) and SERK1 (MKK4), MAPKKs that activate CSBP2 (p38α) and JNK, respectively but cannot phosphorylate PRKMK1 (MKK1), an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the p38 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.^[6]