MAP3K7

MAP3K7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EVA, 2YIY, 4GS6, 4L3P, 4L52, 4L53, 4O91, 5JGD, 5JGA
Identifiers
Aliases	MAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF
External IDs	OMIM: 602614; MGI: 1346877; HomoloGene: 135715; GeneCards: MAP3K7; OMA:MAP3K7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 90,513,573 bp[1] End 90,587,072 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 31,964,097 bp[2] End 32,023,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii corpus epididymis internal globus pallidus stromal cell of endometrium tail of epididymis caput epididymis ganglionic eminence corpus callosum Brodmann area 23 Achilles tendon Top expressed in genital tubercle tail of embryo Paneth cell molar aortic valve ventricular zone maxillary prominence somite vastus lateralis muscle mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding scaffold protein binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding MAP kinase kinase kinase activity identical protein binding receptor tyrosine kinase binding Cellular component cytosol membrane plasma membrane endosome membrane nucleus IkappaB kinase complex cytoplasm Biological process regulation of transcription, DNA-templated phosphorylation positive regulation of JUN kinase activity stimulatory C-type lectin receptor signaling pathway activation of NF-kappaB-inducing kinase activity I-kappaB phosphorylation MyD88-dependent toll-like receptor signaling pathway transcription, DNA-templated Fc-epsilon receptor signaling pathway protein phosphorylation JNK cascade positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of interleukin-2 production positive regulation of T cell cytokine production histone H3 acetylation positive regulation of I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling transforming growth factor beta receptor signaling pathway T cell receptor signaling pathway nucleotide-binding oligomerization domain containing signaling pathway signal transduction apoptotic process Wnt signaling pathway, calcium modulating pathway stress-activated MAPK cascade positive regulation of macroautophagy protein deubiquitination anoikis MyD88-independent toll-like receptor signaling pathway viral process interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6885 26409 Ensembl ENSG00000135341 ENSMUSG00000028284 UniProt O43318 Q62073 RefSeq (mRNA) NM_003188 NM_145331 NM_145332 NM_145333 NM_009316 NM_172688 RefSeq (protein) NP_003179 NP_663304 NP_663305 NP_663306 NP_033342 NP_766276 Location (UCSC) Chr 6: 90.51 – 90.59 Mb Chr 4: 31.96 – 32.02 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene.^[5]