MAP3K8

MAP3K8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Y83, 4Y85
Identifiers
Aliases	MAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, AURA2, mitogen-activated protein kinase kinase kinase 8, Tpl2
External IDs	OMIM: 191195; MGI: 1346878; HomoloGene: 3812; GeneCards: MAP3K8; OMA:MAP3K8 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	30,461,833 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	4,353,015 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; mucosa of paranasal sinus; ; upper lobe of left lung; ; left uterine tube; ; germinal epithelium; ; monocyte; ; olfactory zone of nasal mucosa; ; Achilles tendon; ; tibial nerve; ; right lung;
	Top expressed in
	granulocyte; ; saccule; ; lip; ; otic placode; ; skin of external ear; ; stroma of bone marrow; ; spleen; ; otic vesicle; ; hair follicle; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; kinase activity; protein binding; ATP binding; magnesium ion binding; MAP kinase kinase kinase activity; protein serine/threonine kinase activity;
Cellular component	cytosol; cytoplasm;
Biological process	phosphorylation; immune system process; T cell costimulation; stress-activated MAPK cascade; cell cycle; signal transduction; protein phosphorylation; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1326
	26410
	ENSG00000107968
	ENSMUSG00000024235
	P41279
	Q07174
	NM_001244134; NM_005204; NM_001320961
	NM_007746
	NP_001231063; NP_001307890; NP_005195
	NP_031772
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107968 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024235 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T (Aug 1991). "Structure and transforming potential of the human cot oncogene encoding a putative protein kinase". Molecular and Cellular Biology. 11 (8): 4088–96. doi:10.1128/mcb.11.8.4088. PMC 361219. PMID 2072910.
^ Chan AM, Chedid M, McGovern ES, Popescu NC, Miki T, Aaronson SA (May 1993). "Expression cDNA cloning of a serine kinase transforming gene". Oncogene. 8 (5): 1329–33. PMID 8479752.
^ "Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107968 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024235 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2072910-5] Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T (Aug 1991). "Structure and transforming potential of the human cot oncogene encoding a putative protein kinase". Molecular and Cellular Biology. 11 (8): 4088–96. doi:10.1128/mcb.11.8.4088. PMC 361219. PMID 2072910.

[pmid8479752-6] Chan AM, Chedid M, McGovern ES, Popescu NC, Miki T, Aaronson SA (May 1993). "Expression cDNA cloning of a serine kinase transforming gene". Oncogene. 8 (5): 1329–33. PMID 8479752.

[entrez-7] "Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8".

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