MAP4K2

MAP4K2
Identifiers
Aliases	MAP4K2, BL44, GCK, RAB8IP, mitogen-activated protein kinase kinase kinase kinase 2
External IDs	OMIM: 603166; MGI: 1346883; HomoloGene: 3370; GeneCards: MAP4K2; OMA:MAP4K2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,803,241 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,405,645 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; right lung; ; monocyte; ; right hemisphere of cerebellum; ; lymph node; ; gonad; ; right frontal lobe; ; upper lobe of left lung; ; prefrontal cortex;
	Top expressed in
	granulocyte; ; thymus; ; cerebellum; ; spleen; ; cerebellar cortex; ; neural layer of retina; ; hypothalamus; ; striatum of neuraxis; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; mitogen-activated protein kinase kinase kinase binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase kinase kinase activity;
Cellular component	Golgi apparatus; membrane; Golgi membrane; plasma membrane; basolateral plasma membrane; cytoplasm;
Biological process	intracellular signal transduction; vesicle targeting; phosphorylation; immune system process; positive regulation of JNK cascade; protein phosphorylation; JNK cascade; immune response; innate immune response; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5871
	26412
	ENSG00000168067
	ENSMUSG00000024948
	Q12851
	Q61161
	NM_001307990; NM_004579
	NM_001291787; NM_009006
	NP_001294919; NP_004570
	NP_001278716; NP_033032
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168067 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024948 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Katz P, Whalen G, Kehrl JH (Jun 1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center". The Journal of Biological Chemistry. 269 (24): 16802–9. doi:10.1016/S0021-9258(19)89463-2. PMID 7515885.
^ "Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168067 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024948 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7515885-5] Katz P, Whalen G, Kehrl JH (Jun 1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center". The Journal of Biological Chemistry. 269 (24): 16802–9. doi:10.1016/S0021-9258(19)89463-2. PMID 7515885.

[entrez-6] "Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2".

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