MAPK10

MAPK10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JNK, 1PMN, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B, 4KKG, 4KKH, 4U79, 4W4V, 4W4W, 4W4X, 4W4Y, 4WHZ, 4Y46, 4Y5H, 4Z9L, 4X21
Identifiers
Aliases	MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10
External IDs	OMIM: 602897; MGI: 1346863; HomoloGene: 56439; GeneCards: MAPK10; OMA:MAPK10 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	86,594,625 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	103,359,200 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; primary visual cortex; ; middle temporal gyrus; ; Brodmann area 23; ; cingulate gyrus; ; anterior cingulate cortex; ; endothelial cell; ; frontal pole;
	Top expressed in
	substantia nigra; ; motor neuron; ; medial vestibular nucleus; ; anterior amygdaloid area; ; subiculum; ; medial geniculate nucleus; ; prefrontal cortex; ; medial dorsal nucleus; ; primary motor cortex; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; MAP kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase activity; JUN kinase activity;
Cellular component	cytosol; membrane; mitochondrion; plasma membrane; nucleus; cytoplasm; neuron projection; nucleoplasm; perikaryon; glutamatergic synapse; intracellular anatomical structure;
Biological process	phosphorylation; response to light stimulus; rhythmic process; Fc-epsilon receptor signaling pathway; protein phosphorylation; regulation of circadian rhythm; signal transduction; JUN phosphorylation; JNK cascade; regulation of gene expression; neuron development; intracellular signal transduction; cellular response to organic substance; negative regulation of transcription by RNA polymerase II; response to water deprivation; cellular hyperosmotic response; neurotransmitter receptor transport to postsynaptic membrane; vesicle-mediated transport in synapse; regulation of DNA-binding transcription factor activity; MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	5602
	26414
	ENSG00000109339
	ENSMUSG00000046709
	P53779; Q499Y8
	Q61831
NM_002753; NM_138980; NM_138981; NM_138982; NM_001318067;
	NM_001318068; NM_001318069; NM_001351624; NM_001351625; NM_001363657
NM_001081567; NM_009158; NM_001310683; NM_001310685; NM_001310686;
	NM_001318102; NM_001318131
NP_001304996; NP_001304997; NP_001304998; NP_002744; NP_620446;
	NP_620448; NP_001338553; NP_001338554; NP_001350586; NP_001304997.1
NP_001075036; NP_001297612; NP_001297614; NP_001297615; NP_001305031;
	NP_001305060; NP_033184; NP_001394501; NP_001394502; NP_001394503; NP_001394504; NP_001394505; NP_001394506; NP_001394507; NP_001394508; NP_001394509; NP_001394513; NP_001394515; NP_001394517; NP_001394518; NP_001394521; NP_001394524; NP_001394528; NP_001394529; NP_001394530
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109339 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046709 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. doi:10.1002/j.1460-2075.1996.tb00636.x. PMC 450211. PMID 8654373.
^ Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002). "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". J. Hum. Genet. 47 (11): 614–9. doi:10.1007/s100380200094. PMID 12436199.
^ "Entrez Gene: MAPK10 mitogen-activated protein kinase 10".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109339 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046709 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8654373-5] Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. doi:10.1002/j.1460-2075.1996.tb00636.x. PMC 450211. PMID 8654373.

[pmid12436199-6] Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002). "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". J. Hum. Genet. 47 (11): 614–9. doi:10.1007/s100380200094. PMID 12436199.

[entrez-7] "Entrez Gene: MAPK10 mitogen-activated protein kinase 10".

[1]

[2]

[3]

[4]

[5]

[6]

[7]