MAPK11

MAPK11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GC8, 3GC9, 3GP0
Identifiers
Aliases	MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, mitogen-activated protein kinase 11
External IDs	OMIM: 602898; MGI: 1338024; HomoloGene: 55684; GeneCards: MAPK11; OMA:MAPK11 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,270,767 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,033,831 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; Brodmann area 9; ; middle temporal gyrus; ; cingulate gyrus; ; anterior cingulate cortex; ; apex of heart; ; caudate nucleus; ; Brodmann area 23; ; putamen;
	Top expressed in
	lumbar spinal ganglion; ; ventricular zone; ; visual cortex; ; primary visual cortex; ; tail of embryo; ; superior frontal gyrus; ; superior cervical ganglion; ; ganglionic eminence; ; primary motor cortex; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; MAP kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	regulation of transcription, DNA-templated; regulation of cardiac muscle cell proliferation; positive regulation of erythrocyte differentiation; phosphorylation; positive regulation of muscle cell differentiation; transcription, DNA-templated; protein phosphorylation; positive regulation of gene expression; negative regulation of cardiac muscle cell proliferation; regulation of signal transduction by p53 class mediator; stress-activated MAPK cascade; cellular response to interleukin-1; regulation of gene expression; intracellular signal transduction; cellular response to organic substance; Ras protein signal transduction; vascular endothelial growth factor receptor signaling pathway; regulation of DNA-binding transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	5600
	19094
	ENSG00000185386
	ENSMUSG00000053137
	Q15759
	Q9WUI1
	NM_002751
	NM_011161
	NP_002742
	NP_035291
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185386 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053137 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (Aug 1997). "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases". EMBO J. 16 (12): 3563–71. doi:10.1093/emboj/16.12.3563. PMC 1169981. PMID 9218798.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185386 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053137 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9218798-5] Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (Aug 1997). "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases". EMBO J. 16 (12): 3563–71. doi:10.1093/emboj/16.12.3563. PMC 1169981. PMID 9218798.

[entrez-6] Cite error: The named reference entrez was invoked but never defined (see the help page).

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