MAPK14

MAPK14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9U, 1BL6, 1BL7, 1BMK, 1DI9, 1IAN, 1KV1, 1KV2, 1M7Q, 1OUK, 1OUY, 1OVE, 1OZ1, 1R39, 1R3C, 1W7H, 1W82, 1W83, 1W84, 1WBN, 1WBO, 1WBS, 1WBT, 1WBV, 1WBW, 1WFC, 1YQJ, 1ZYJ, 1ZZ2, 1ZZL, 2BAJ, 2BAK, 2BAL, 2BAQ, 2FSL, 2FSM, 2FSO, 2FST, 2GFS, 2I0H, 2LGC, 2NPQ, 2OKR, 2ONL, 2QD9, 2RG5, 2RG6, 2Y8O, 2YIS, 2YIW, 2YIX, 2ZAZ, 2ZB0, 2ZB1, 3BV2, 3BV3, 3BX5, 3C5U, 3CTQ, 3D7Z, 3D83, 3DS6, 3DT1, 3E92, 3E93, 3FI4, 3FKL, 3FKN, 3FKO, 3FL4, 3FLN, 3FLQ, 3FLS, 3FLW, 3FLY, 3FLZ, 3FMH, 3FMJ, 3FMK, 3FML, 3FMM, 3FMN, 3FSF, 3FSK, 3GC7, 3GCP, 3GCQ, 3GCS, 3GCU, 3GCV, 3GFE, 3GI3, 3HA8, 3HEC, 3HEG, 3HL7, 3HLL, 3HP2, 3HP5, 3HRB, 3HUB, 3HUC, 3HV3, 3HV4, 3HV5, 3HV6, 3HV7, 3HVC, 3IPH, 3ITZ, 3IW5, 3IW6, 3IW7, 3IW8, 3K3I, 3K3J, 3KF7, 3KQ7, 3L8S, 3L8X, 3LFA, 3LFB, 3LFC, 3LFD, 3LFE, 3LFF, 3LHJ, 3MGY, 3MH0, 3MH1, 3MH2, 3MH3, 3MPA, 3MPT, 3MVL, 3MVM, 3MW1, 3NEW, 3NNU, 3NNV, 3NNW, 3NNX, 3NWW, 3O8P, 3O8T, 3O8U, 3OBG, 3OBJ, 3OC1, 3OCG, 3OD6, 3ODY, 3ODZ, 3OEF, 3PG3, 3QUD, 3QUE, 3RIN, 3ROC, 3S3I, 3S4Q, 3U8W, 3UVP, 3UVQ, 3UVR, 3ZS5, 3ZSG, 3ZSH, 3ZSI, 3ZYA, 4A9Y, 4AA0, 4AA4, 4AA5, 4AAC, 4DLI, 4DLJ, 4E5A, 4E5B, 4E6A, 4E6C, 4E8A, 4EH2, 4EH3, 4EH4, 4EH5, 4EH6, 4EH7, 4EH8, 4EH9, 4EHV, 4EWQ, 4F9W, 4F9Y, 4FA2, 4GEO, 4KIN, 4KIP, 4KIQ, 4L8M, 3FC1, 4R3C, 5ETC, 5ETI, 4ZTH
Identifiers
Aliases	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, mitogen-activated protein kinase 14
External IDs	OMIM: 600289; MGI: 1346865; HomoloGene: 31777; GeneCards: MAPK14; OMA:MAPK14 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 36,027,677 bp[1] End 36,111,236 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 14.85 cM Start 28,910,303 bp[2] End 28,967,380 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell blood bone marrow bone marrow cells monocyte trabecular bone Achilles tendon endothelial cell granulocyte stromal cell of endometrium Top expressed in granulocyte renal corpuscle medullary collecting duct blood conjunctival fornix knee joint triceps brachii muscle primitive streak masseter muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity protein phosphatase binding ATP binding protein kinase activity MAP kinase activity protein serine/threonine kinase activity enzyme binding NFAT protein binding transferase activity protein binding nucleotide binding MAP kinase kinase activity mitogen-activated protein kinase p38 binding Cellular component cytosol mitochondrion spindle pole extracellular region nucleoplasm nuclear speck secretory granule lumen ficolin-1-rich granule lumen nucleus cytoplasm glutamatergic synapse Biological process positive regulation of glucose import positive regulation of muscle cell differentiation placenta development regulation of transcription by RNA polymerase II cellular response to DNA damage stimulus protein phosphorylation cell surface receptor signaling pathway positive regulation of reactive oxygen species metabolic process positive regulation of cardiac muscle cell proliferation fatty acid oxidation angiogenesis positive regulation of blood vessel endothelial cell migration glucose metabolic process cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway apoptotic process response to muscle stretch regulation of transcription, DNA-templated positive regulation of erythrocyte differentiation stress-induced premature senescence osteoclast differentiation response to muramyl dipeptide transcription, DNA-templated p38MAPK cascade positive regulation of protein import into nucleus 3'-UTR-mediated mRNA stabilization myoblast differentiation involved in skeletal muscle regeneration chondrocyte differentiation phosphorylation signal transduction in response to DNA damage chemotaxis positive regulation of myoblast fusion response to lipopolysaccharide positive regulation of cyclase activity cartilage condensation lipopolysaccharide-mediated signaling pathway positive regulation of myotube differentiation intracellular signal transduction regulation of cytokine production involved in inflammatory response DNA damage checkpoint signaling positive regulation of gene expression transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of myoblast differentiation peptidyl-serine phosphorylation cell morphogenesis striated muscle cell differentiation cellular response to vascular endothelial growth factor stimulus cellular response to lipopolysaccharide positive regulation of brown fat cell differentiation skeletal muscle tissue development positive regulation of transcription by RNA polymerase II signal transduction regulation of signal transduction by p53 class mediator regulation of ossification neutrophil degranulation positive regulation of macrophage chemotaxis positive regulation of metallopeptidase activity cellular response to lipoteichoic acid cellular response to tumor necrosis factor vascular endothelial growth factor receptor signaling pathway regulation of synaptic membrane adhesion regulation of gene expression cellular response to organic substance Ras protein signal transduction regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1432 26416 Ensembl ENSG00000112062 ENSMUSG00000053436 UniProt Q16539 P47811 RefSeq (mRNA) NM_001315 NM_139012 NM_139013 NM_139014 NM_001168508 NM_001168513 NM_001168514 NM_011951 NM_001357724 RefSeq (protein) NP_001306 NP_620581 NP_620582 NP_620583 NP_001161980 NP_001161985 NP_001161986 NP_036081 NP_001344653 Location (UCSC) Chr 6: 36.03 – 36.11 Mb Chr 17: 28.91 – 28.97 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene.^[5]

MAPK14 encodes p38α mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family. p38 MAPKs are also known as stress-activated serine/threonine-specific kinases (SAPKs). In addition to MAPK14 for p38α MAPK, the p38 MAPK family has three additional members, including MAPK11, MAPK12 and MAPK13 which encodes p38β MAPK, p38γ MAPK and p38δ MAPK isoforms, respectively. p38α MAPK was originally identified as a tyrosine phosphorylated protein detected in activated immune cell macrophages with an essential role in inflammatory cytokine induction, such as Tumor Necrotic Factor α (TNFα).^[6][7] However, p38α MAPK mediated kinase activity has been implicated in many tissues beyond immune systems. p38α MAPK is mainly activated through MAPK kinase kinase cascades and exerts its biological function via downstream substrate phosphorylation. p38α MAPK is implicated in diverse cellular functions, from gene expression to programmed cell death through a network of signaling molecules and transcription factors. Pharmacological and genetic inhibition of p38α MAPK not only revealed its biological significance in physiological function but also the potential of targeting p38α MAPK in human disease such as immune disorders and heart failure.