MAPKAPK2

MAPKAPK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KWP, 1NXK, 1NY3, 2JBO, 2JBP, 2OKR, 2ONL, 2OZA, 2P3G, 2PZY, 3A2C, 3FPM, 3FYJ, 3FYK, 3GOK, 3KA0, 3KC3, 3KGA, 3M2W, 3M42, 3R2B, 3R2Y, 3R30, 3WI6, 4TYH
Identifiers
Aliases	MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2, MAPK activated protein kinase 2
External IDs	OMIM: 602006; MGI: 109298; HomoloGene: 56412; GeneCards: MAPKAPK2; OMA:MAPKAPK2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,734,281 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,025,563 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle; ; left ventricle; ; gastrocnemius muscle; ; muscle of thigh; ; myocardium of left ventricle; ; stromal cell of endometrium; ; upper lobe of left lung; ; right lung; ; islet of Langerhans;
	Top expressed in
	plantaris muscle; ; muscle of thigh; ; interventricular septum; ; extensor digitorum longus muscle; ; granulocyte; ; soleus muscle; ; skeletal muscle tissue; ; myocardium of ventricle; ; thoracic diaphragm; ; extraocular muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calmodulin-dependent protein kinase activity; signal transducer activity; nucleotide binding; transferase activity; kinase activity; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; mitogen-activated protein kinase binding;
Cellular component	extracellular exosome; cytosol; centrosome; nucleoplasm; cytoplasm; nucleus;
Biological process	response to stress; MAPK cascade; regulation of mRNA stability; response to cytokine; peptidyl-serine phosphorylation; cellular response to vascular endothelial growth factor stimulus; mRNA stabilization; protein autophosphorylation; 3'-UTR-mediated mRNA stabilization; cellular response to DNA damage stimulus; inner ear development; p38MAPK cascade; Ras protein signal transduction; leukotriene metabolic process; regulation of cellular response to heat; phosphorylation; protein phosphorylation; regulation of interleukin-6 production; vascular endothelial growth factor receptor signaling pathway; response to lipopolysaccharide; inflammatory response; macropinocytosis; regulation of tumor necrosis factor production; toll-like receptor signaling pathway; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9261
	17164
	ENSG00000162889
	ENSMUSG00000016528
	P49137
	P49138
	NM_004759; NM_032960
	NM_008551
	NP_004750; NP_116584
	NP_032577
	Wikidata
View/Edit Human	View/Edit Mouse

MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162889 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016528 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zu YL, Wu F, Gilchrist A, et al. (April 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochemical and Biophysical Research Communications. 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591.
^ Stokoe D, Caudwell B, Cohen PT, et al. (December 1993). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". The Biochemical Journal. 296 ( Pt 3) (Pt 3): 843–9. doi:10.1042/bj2960843. PMC 1137771. PMID 8280084.
^ Liu T, Warburton RR, Hill NS, et al. (August 2015). "Anthrax lethal toxin-induced lung injury and treatment by activating MK2". Journal of Applied Physiology. 119 (4): 412–9. doi:10.1152/japplphysiol.00335.2015. PMC 4538279. PMID 26066827.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162889 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016528 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8179591-5] Zu YL, Wu F, Gilchrist A, et al. (April 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochemical and Biophysical Research Communications. 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591.

[pmid8280084-6] Stokoe D, Caudwell B, Cohen PT, et al. (December 1993). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". The Biochemical Journal. 296 ( Pt 3) (Pt 3): 843–9. doi:10.1042/bj2960843. PMC 1137771. PMID 8280084.

[Liu_412–419-7] Liu T, Warburton RR, Hill NS, et al. (August 2015). "Anthrax lethal toxin-induced lung injury and treatment by activating MK2". Journal of Applied Physiology. 119 (4): 412–9. doi:10.1152/japplphysiol.00335.2015. PMC 4538279. PMID 26066827.

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