MAX (gene)

MAX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AN2, 1HLO, 1NKP, 1NLW, 1R05
Identifiers
Aliases	MAX, bHLHd4, max, MYC associated factor X
External IDs	OMIM: 154950; MGI: 96921; HomoloGene: 1786; GeneCards: MAX; OMA:MAX - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	65,102,695 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	77,008,975 bp
RNA expression pattern
	Top expressed in
	monocyte; ; tendon of biceps brachii; ; oocyte; ; secondary oocyte; ; epithelium of nasopharynx; ; blood; ; olfactory bulb; ; dorsal motor nucleus of vagus nerve; ; Achilles tendon; ; granulocyte;
	Top expressed in
	granulocyte; ; tail of embryo; ; genital tubercle; ; zygote; ; neural layer of retina; ; lip; ; esophagus; ; yolk sac; ; muscle of thigh; ; secondary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity; transcription coactivator activity; transcription coregulator activity; RNA polymerase II general transcription initiation factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA binding; protein homodimerization activity; E-box binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding; protein heterodimerization activity;
Cellular component	PML body; cell projection; dendrite; nucleus; nucleoplasm; cytoplasm; protein-DNA complex; MLL1 complex; RNA polymerase II transcription regulator complex;
Biological process	neuron apoptotic process; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; cellular response to starvation; transcription by RNA polymerase II; negative regulation of gene expression; transcription, DNA-templated; response to insulin; cellular response to peptide hormone stimulus; retina development in camera-type eye; response to axon injury; response to organonitrogen compound; negative regulation of transcription by RNA polymerase II; negative regulation of G0 to G1 transition; G1/S transition of mitotic cell cycle; protein-containing complex assembly; positive regulation of nucleic acid-templated transcription; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4149
	17187
	ENSG00000125952
	ENSMUSG00000059436
	P61244; Q8TAX8
	P28574
NM_001271068; NM_001271069; NM_002382; NM_145112; NM_145113;
	NM_145114; NM_145116; NM_197957; NM_001320415
	NM_001146176; NM_008558; NM_001361663; NM_001361664
NP_001257997; NP_001257998; NP_001307344; NP_002373; NP_660087;
	NP_660088; NP_660089; NP_932061; NP_002373.3; NP_660087.1; NP_660088.1; NP_001307344.1
	NP_001139648; NP_001348592; NP_001348593; NP_032584
	Wikidata
View/Edit Human	View/Edit Mouse

MAX (also known as myc-associated factor X) is a gene that in humans encodes the MAX transcription factor.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125952 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059436 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wagner AJ, Le Beau MM, Diaz MO, Hay N (April 1992). "Expression, regulation, and chromosomal localization of the Max gene". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 3111–3115. Bibcode:1992PNAS...89.3111W. doi:10.1073/pnas.89.7.3111. PMC 48814. PMID 1557420.
^ "Entrez Gene: MAX MYC associated factor X".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125952 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059436 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1557420-5] Wagner AJ, Le Beau MM, Diaz MO, Hay N (April 1992). "Expression, regulation, and chromosomal localization of the Max gene". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 3111–3115. Bibcode:1992PNAS...89.3111W. doi:10.1073/pnas.89.7.3111. PMC 48814. PMID 1557420.

[entrez-6] "Entrez Gene: MAX MYC associated factor X".

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