MCF2

MCF2
Identifiers
Aliases	MCF2, ARHGEF21, DBL, MCF.2 cell line derived transforming sequence
External IDs	OMIM: 311030; MGI: 96932; HomoloGene: 3917; GeneCards: MCF2; OMA:MCF2 - orthologs
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	59,224,449 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; endothelial cell; ; Brodmann area 23; ; hypothalamus; ; Brodmann area 9; ; prefrontal cortex; ; substantia nigra; ; pons; ; middle temporal gyrus; ; nucleus accumbens;
	Top expressed in
	lumbar subsegment of spinal cord; ; facial motor nucleus; ; anterior horn of spinal cord; ; epiblast; ; embryo; ; zygote; ; spermatocyte; ; embryo; ; substantia nigra; ; lateral geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; cytoskeleton; membrane;
Biological process	regulation of Rho protein signal transduction; intracellular signal transduction; regulation of small GTPase mediated signal transduction; positive regulation of apoptotic process; G protein-coupled receptor signaling pathway; negative regulation of axonogenesis; dendrite development; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	4168
	109904
	n/a
	ENSMUSG00000031139
	P10911
	n/a
NM_001099855; NM_001171876; NM_001171877; NM_001171878; NM_001171879;
	NM_005369
NM_001289730; NM_001289731; NM_133197; NM_001358998; NM_001358999;
	NM_001359000; NM_001359001
NP_001093325; NP_001165347; NP_001165348; NP_001165349; NP_001165350;
	NP_005360
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene.^[4]^[5]^[6]

The commonly-used name DBL is derived from “diffuse B-cell lymphoma”, the cancer type where this gene was first identified as an oncogene,^[7] while the name MCF2 name derives from “MCF.2 cell line-derived transforming sequence”.^[8]

DBL is the founding member of a large family of guanine nucleotide exchange factors that share a common DBL-homology (DH) domain), so DBL is also named as a member of this RhoGEF family as ARHGEF21. DH domains function to activate small GTPases of the Rho family by facilitating release of GDP from an inactive Rho GTPase and binding of GTP to activate it. In particular, DBL activates the Rho family member Cdc42.^[9]

Gene recombinations that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM]^[6]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031139 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (December 1988). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15. PMID 2577874.
^ Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
^ ^a ^b "Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence".
^ Eva A, Aaronson SA (1985-07-18). "Isolation of a new human oncogene from a diffuse B-cell lymphoma". Nature. 316 (6025): 273–5. Bibcode:1985Natur.316..273E. doi:10.1038/316273a0. PMID 3875039. S2CID 4268140.
^ Noguchi T, Mattei MG, Oberlè I, Planche J, Imbert J, Pelassy C, et al. (May 1987). "Localization of the mcf.2 transforming sequence to the X chromosome". The EMBO Journal. 6 (5): 1301–7. doi:10.1002/j.1460-2075.1987.tb02368.x. PMC 553933. PMID 3038515.
^ Fort P, Blangy A (June 2017). "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals". Genome Biology and Evolution. 9 (6): 1471–1486. doi:10.1093/gbe/evx100. PMC 5499878. PMID 28541439.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000031139 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2577874-4] Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (December 1988). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15. PMID 2577874.

[pmid1611909-5] Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.

[entrez-6] "Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence".

[pmid3875039-7] Eva A, Aaronson SA (1985-07-18). "Isolation of a new human oncogene from a diffuse B-cell lymphoma". Nature. 316 (6025): 273–5. Bibcode:1985Natur.316..273E. doi:10.1038/316273a0. PMID 3875039. S2CID 4268140.

[pmid3038515-8] Noguchi T, Mattei MG, Oberlè I, Planche J, Imbert J, Pelassy C, et al. (May 1987). "Localization of the mcf.2 transforming sequence to the X chromosome". The EMBO Journal. 6 (5): 1301–7. doi:10.1002/j.1460-2075.1987.tb02368.x. PMC 553933. PMID 3038515.

[pmid28541439-9] Fort P, Blangy A (June 2017). "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals". Genome Biology and Evolution. 9 (6): 1471–1486. doi:10.1093/gbe/evx100. PMC 5499878. PMID 28541439.

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