MCM3

MCM3
Identifiers
Aliases	MCM3, HCC5, P1-P1.h, RLFB, minichromosome maintenance complex component 3
External IDs	OMIM: 602693; MGI: 101845; HomoloGene: 1791; GeneCards: MCM3; OMA:MCM3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	52,284,881 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	20,890,536 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; mucosa of transverse colon; ; appendix; ; rectum; ; lymph node; ; gonad; ; trabecular bone; ; body of uterus;
	Top expressed in
	somite; ; epiblast; ; mandibular prominence; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence; ; ventricular zone; ; primitive streak; ; tail of embryo; ; otic placode; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; protein binding; hydrolase activity; ATP binding; DNA replication origin binding; single-stranded DNA binding;
Cellular component	cytoplasm; centrosome; membrane; nucleoplasm; perinuclear region of cytoplasm; alpha DNA polymerase:primase complex; MCM complex; nucleus; nucleolus; intracellular membrane-bounded organelle;
Biological process	G1 phase; DNA replication; DNA replication initiation; cell cycle; G1/S transition of mitotic cell cycle; double-strand break repair via break-induced replication; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; DNA strand elongation involved in DNA replication; mitotic DNA replication initiation;
	Sources:Amigo / QuickGO
Orthologs
	4172
	17215
	ENSG00000112118
	ENSMUSG00000041859
	P25205; Q7Z6P5
	P25206
	NM_002388; NM_001270472
	NM_008563
NP_001257401; NP_002379; NP_001353298; NP_001353299; NP_001353300;
	NP_001353301; NP_001353302; NP_001353303; NP_001353304
	NP_032589
	Wikidata
View/Edit Human	View/Edit Mouse

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112118 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041859 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thömmes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R (April 1992). "Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein". Nucleic Acids Res. 20 (5): 1069–74. doi:10.1093/nar/20.5.1069. PMC 312092. PMID 1549468.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112118 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041859 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1549468-5] Thömmes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R (April 1992). "Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein". Nucleic Acids Res. 20 (5): 1069–74. doi:10.1093/nar/20.5.1069. PMC 312092. PMID 1549468.

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