MCM5

MCM5
Identifiers
Aliases	MCM5, CDC46, P1-CDC46, minichromosome maintenance complex component 5, MGORS8
External IDs	OMIM: 602696; MGI: 103197; HomoloGene: 4904; GeneCards: MCM5; OMA:MCM5 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,425,431 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	75,855,067 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; appendix; ; granulocyte; ; bone marrow cells; ; lymph node; ; spleen; ; monocyte; ; gonad; ; rectum;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; primitive streak; ; maxillary prominence; ; mandibular prominence; ; abdominal wall; ; vas deferens; ; Gonadal ridge; ; endocardial cushion; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; DNA helicase activity; DNA replication origin binding; chromatin binding; protein binding; hydrolase activity; ATP binding; helicase activity; single-stranded DNA binding; single-stranded DNA helicase activity; 3'-5' DNA helicase activity;
Cellular component	MCM complex; membrane; nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	G1 phase; DNA replication; cell cycle; DNA duplex unwinding; DNA replication initiation; G1/S transition of mitotic cell cycle; double-strand break repair via break-induced replication; pre-replicative complex assembly involved in nuclear cell cycle DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	4174
	17218
	ENSG00000100297
	ENSMUSG00000005410
	P33992
	P49718
	NM_006739
	NM_008566; NM_001302540
	NP_006730
	NP_001289469; NP_032592
	Wikidata
View/Edit Human	View/Edit Mouse

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100297 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005410 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5". Cytogenet Cell Genet. 73 (4): 317–21. doi:10.1159/000134366. PMID 8751386.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100297 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005410 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8751386-5] Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5". Cytogenet Cell Genet. 73 (4): 317–21. doi:10.1159/000134366. PMID 8751386.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-7] "Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]