MCM6

MCM6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KLQ, 2LE8
Identifiers
Aliases	MCM6, MCG40308, Mis5, P105MCM, minichromosome maintenance complex component 6
External IDs	OMIM: 601806; MGI: 1298227; HomoloGene: 4322; GeneCards: MCM6; OMA:MCM6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	135,876,443 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	128,287,401 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; trabecular bone; ; endothelial cell; ; gonad; ; glomerulus; ; secondary oocyte; ; metanephric glomerulus; ; bone marrow;
	Top expressed in
	somite; ; Paneth cell; ; mandibular prominence; ; abdominal wall; ; hand; ; maxillary prominence; ; fetal liver hematopoietic progenitor cell; ; primitive streak; ; Gonadal ridge; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; single-stranded DNA binding; nucleotide binding; DNA helicase activity; DNA binding; protein binding; hydrolase activity; ATP binding; helicase activity; DNA replication origin binding; single-stranded 3'-5' DNA helicase activity;
Cellular component	MCM complex; nucleus; nucleoplasm;
Biological process	G1 phase; DNA replication; cell cycle; DNA replication initiation; DNA unwinding involved in DNA replication; G1/S transition of mitotic cell cycle; double-strand break repair via break-induced replication; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; mitotic DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	4175
	17219
	ENSG00000076003
	ENSMUSG00000026355
	Q14566
	P97311
	NM_005915
	NM_008567; NM_001313695
	NP_005906
	NP_001300624; NP_032593
	Wikidata
View/Edit Human	View/Edit Mouse

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene.^[5] MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076003 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Harvey CB, Wang Y, Darmoul D, Phillips A, Mantei N, Swallow DM (December 1996). "Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21". FEBS Lett. 398 (2–3): 135–40. doi:10.1016/S0014-5793(96)01189-1. PMID 8977093. S2CID 1323113.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076003 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8977093-5] Harvey CB, Wang Y, Darmoul D, Phillips A, Mantei N, Swallow DM (December 1996). "Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21". FEBS Lett. 398 (2–3): 135–40. doi:10.1016/S0014-5793(96)01189-1. PMID 8977093. S2CID 1323113.

[1]

[2]

[3]

[4]

[5]