MECOM

MECOM
Identifiers
Aliases	MECOM, AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2, MDS1 and EVI1 complex locus, KMT8E
External IDs	OMIM: 165215; MGI: 95457; HomoloGene: 21086; GeneCards: MECOM; OMA:MECOM - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 169,083,499 bp[1] End 169,663,775 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A3|3 12.66 cM Start 30,005,445 bp[2] End 30,602,157 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardia renal medulla pylorus nasal epithelium mucosa of paranasal sinus bronchial epithelial cell visceral pleura mucosa of urinary bladder mucosa of sigmoid colon lower lobe of lung Top expressed in transitional epithelium of urinary bladder epithelium of stomach Paneth cell left lung lobe renal corpuscle medullary collecting duct endocardial cushion left colon lacrimal gland ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein homodimerization activity metal ion binding protein binding nucleic acid binding histone-lysine N-methyltransferase activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity histone methyltransferase activity (H3-K9 specific) methyltransferase activity transferase activity Cellular component histone deacetylase complex cytosol nuclear speck nucleus nucleoplasm cytoplasm Biological process cell differentiation regulation of transcription, DNA-templated hematopoietic stem cell proliferation negative regulation of transforming growth factor beta receptor signaling pathway transcription, DNA-templated regulation of cell cycle positive regulation of transcription, DNA-templated multicellular organism development negative regulation of JNK cascade negative regulation of programmed cell death negative regulation of transcription, DNA-templated apoptotic process histone lysine methylation regulation of transcription by RNA polymerase II histone H3-K9 methylation heterochromatin organization methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2122 14013 Ensembl ENSG00000085276 ENSMUSG00000027684 UniProt Q03112 P14404 RefSeq (mRNA) NM_001105077 NM_001105078 NM_001163999 NM_001164000 NM_001205194 NM_004991 NM_005241 NM_001366466 NM_001366467 NM_001366468 NM_001366469 NM_001366470 NM_001366471 NM_001366472 NM_001366473 NM_001366474 NM_007963 NM_021442 NM_001361034 NM_001370768 NM_001370769 RefSeq (protein) NP_001098547 NP_001098548 NP_001157471 NP_001157472 NP_001192123 NP_004982 NP_005232 NP_001353395 NP_001353396 NP_001353397 NP_001353398 NP_001353399 NP_001353400 NP_001353401 NP_001353402 NP_001353403 NP_004982.2 NP_031989 NP_067417 NP_001347963 NP_001357697 NP_001357698 NP_067417.1 Location (UCSC) Chr 3: 169.08 – 169.66 Mb Chr 3: 30.01 – 30.6 Mb PubMed search [3] [4]
Wikidata
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MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.