MEF2B

BORCS8-MEF2B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1N6J, 1TQE
Identifiers
Aliases	BORCS8-MEF2B, LOC729991-MEF2B, MEF2B, MEF2BNB-MEF2B, BORCS8-MEF2B readthrough, RSRFR2
External IDs	GeneCards: BORCS8-MEF2B; OMA:BORCS8-MEF2B - orthologs
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; protein dimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex;
Biological process	muscle organ development; regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4207
	n/a
	ENSG00000064489
	n/a
	Q02080
	n/a
	NM_005919
	n/a
	NP_001139257; NP_001354211; NP_005910.1
	n/a
	Wikidata
View/Edit Human

Myocyte enhancer binding factor 2B (MEF2B) is a transcription factor part of the MEF2 gene family including MEF2A, MEF2C, and MEF2D.^[2]^[3] However, MEF2B is distant from the other three branches of MEF2 genes as it lacks the protein-coding Holliday junction recognition protein C-terminal (HJURP_C) region in vertebrates.^[4]

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krenács D, Borbényi Z, Bedekovics J, Méhes G, Bagdi E, Krenács L (September 2015). "Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas". Virchows Archiv. 467 (3): 345–355. doi:10.1007/s00428-015-1796-6. PMID 26089142. S2CID 25535467.
^ Rodríguez AI, Csányi G, Ranayhossaini DJ, Feck DM, Blose KJ, Assatourian L, et al. (February 2015). "MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 35 (2): 430–438. doi:10.1161/ATVBAHA.114.304936. PMC 4409426. PMID 25550204.
^ Wu W, de Folter S, Shen X, Zhang W, Tao S (March 2011). "Vertebrate paralogous MEF2 genes: origin, conservation, and evolution". PLOS ONE. 6 (3): e17334. Bibcode:2011PLoSO...617334W. doi:10.1371/journal.pone.0017334. PMC 3048864. PMID 21394201.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] Krenács D, Borbényi Z, Bedekovics J, Méhes G, Bagdi E, Krenács L (September 2015). "Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas". Virchows Archiv. 467 (3): 345–355. doi:10.1007/s00428-015-1796-6. PMID 26089142. S2CID 25535467.

[3] Rodríguez AI, Csányi G, Ranayhossaini DJ, Feck DM, Blose KJ, Assatourian L, et al. (February 2015). "MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 35 (2): 430–438. doi:10.1161/ATVBAHA.114.304936. PMC 4409426. PMID 25550204.

[:0-4] Wu W, de Folter S, Shen X, Zhang W, Tao S (March 2011). "Vertebrate paralogous MEF2 genes: origin, conservation, and evolution". PLOS ONE. 6 (3): e17334. Bibcode:2011PLoSO...617334W. doi:10.1371/journal.pone.0017334. PMC 3048864. PMID 21394201.

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