MEF2D

MEF2D
Identifiers
Aliases	MEF2D, myocyte enhancer factor 2D
External IDs	OMIM: 600663; MGI: 99533; HomoloGene: 4327; GeneCards: MEF2D; OMA:MEF2D - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,500,779 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,079,393 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; popliteal artery; ; tibial arteries; ; saphenous vein; ; apex of heart; ; sural nerve; ; gastric mucosa; ; canal of the cervix; ; right coronary artery;
	Top expressed in
	Ileal epithelium; ; neural layer of retina; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; plantaris muscle; ; primary visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; protein heterodimerization activity; enzyme binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; chondrocyte differentiation; adult heart development; muscle organ development; endochondral ossification; transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; multicellular organism development; positive regulation of transcription, DNA-templated; osteoblast differentiation; skeletal muscle cell differentiation; positive regulation of transcription by RNA polymerase II; apoptotic process; positive regulation of vascular associated smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4209
	17261
	ENSG00000116604
	ENSMUSG00000001419
	Q14814
	Q63943
	NM_001271629; NM_005920
	NM_133665; NM_001310587; NM_001310593
	NP_001258558; NP_005911
	NP_001297516; NP_001297522; NP_598426
	Wikidata
View/Edit Human	View/Edit Mouse

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001419 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. doi:10.1242/dev.118.4.1095. PMID 8269842.
^ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116604 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001419 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8269842-5] Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. doi:10.1242/dev.118.4.1095. PMID 8269842.

[entrez-6] "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".

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