MHC multimer

MHC multimers are oligomeric forms of MHC molecules, designed to identify and isolate T-cells with high affinity to specific antigens amid a large group of unrelated T-cells.^[1] Multimers generally range in size from dimers to octamers; however, some companies use even higher quantities of MHC per multimer. Multimers may be used to display class 1 MHC, class 2 MHC, or nonclassical molecules (e.g. CD1d) from species such as monkeys, mice, and humans.

^ Hadrup, Sine R.; Bakker, Arnold H.; et al. (2009). "Parallel Detection of Antigen-Specific T-Cell responses by multidimensional encoding of MHC multimers". Nature Methods. 6 (7): 520–526. doi:10.1038/nmeth.1345. PMID 19543285. S2CID 1285613.

[apple-1] Hadrup, Sine R.; Bakker, Arnold H.; et al. (2009). "Parallel Detection of Antigen-Specific T-Cell responses by multidimensional encoding of MHC multimers". Nature Methods. 6 (7): 520–526. doi:10.1038/nmeth.1345. PMID 19543285. S2CID 1285613.

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