MMP23B

MMP23B
Identifiers
Aliases	MMP23B, MIFR, MIFR-1, MMP22, MMP23A, matrix metallopeptidase 23B
External IDs	OMIM: 603321; MGI: 1347361; HomoloGene: 3424; GeneCards: MMP23B; OMA:MMP23B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,635,263 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,737,841 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right ovary; ; left uterine tube; ; right coronary artery; ; left ovary; ; left ventricle; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; granulocyte;
	Top expressed in
	ascending aorta; ; aortic valve; ; calvaria; ; uterus; ; stroma of bone marrow; ; tunica media of zone of aorta; ; body of femur; ; renal corpuscle; ; pericardial cavity; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	integral component of membrane; intracellular anatomical structure; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; extracellular matrix; collagen-containing extracellular matrix; extracellular space;
Biological process	reproduction; proteolysis; extracellular matrix organization; collagen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8510
	26561
	ENSG00000189409
	ENSMUSG00000029061
	O75900
	O88676
	NM_006983
	NM_011985; NM_001320235
	NP_008914
	NP_001307164; NP_036115
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix metalloproteinase-23 is an enzyme that in humans is encoded by the MMP23B gene.^[5]^[6]^[7]

Function

This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the copy of the duplicated region of the gene that is closer to the end of the chromosome (more telemeric).^[7]

MMP23B is strongly expressed in ovary and heart.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189409 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029061 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gururajan R, Grenet J, Lahti JM, Kidd VJ (May 1999). "Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3". Genomics. 52 (1): 101–6. doi:10.1006/geno.1998.5401. PMID 9740677.
^ Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ (Nov 1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2". Genome Res. 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781. PMID 9750192.
^ ^a ^b "Entrez Gene: MMP23B matrix metallopeptidase 23B".
^ Zhao S, Zhao Y, Niu P, Wang N, Tang Z, Zan L, Li K (2011). "Molecular characterization of porcine MMP19 and MMP23B genes and its association with immune traits". Int. J. Biol. Sci. 7 (8): 1101–13. doi:10.7150/ijbs.7.1101. PMC 3174387. PMID 21927579.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189409 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029061 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9740677-5] Gururajan R, Grenet J, Lahti JM, Kidd VJ (May 1999). "Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3". Genomics. 52 (1): 101–6. doi:10.1006/geno.1998.5401. PMID 9740677.

[pmid9750192-6] Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ (Nov 1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2". Genome Res. 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781. PMID 9750192.

[entrez-7] "Entrez Gene: MMP23B matrix metallopeptidase 23B".

[8] Zhao S, Zhao Y, Niu P, Wang N, Tang Z, Zan L, Li K (2011). "Molecular characterization of porcine MMP19 and MMP23B genes and its association with immune traits". Int. J. Biol. Sci. 7 (8): 1101–13. doi:10.7150/ijbs.7.1101. PMC 3174387. PMID 21927579.

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