MOCS2

MOCS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AP8
Identifiers
Aliases	MOCS2, MCBPE, MOCO1, MOCODB, MPTS, molybdenum cofactor synthesis 2
External IDs	OMIM: 603708; MGI: 1336894; HomoloGene: 32193; GeneCards: MOCS2; OMA:MOCS2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	53,110,063 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	114,968,811 bp
RNA expression pattern
	Top expressed in
	anterior cingulate cortex; ; right adrenal gland; ; prefrontal cortex; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; caudate nucleus; ; right frontal lobe; ; right auricle; ; nucleus accumbens;
	Top expressed in
	lens; ; epithelium of lens; ; Paneth cell; ; transitional epithelium of urinary bladder; ; left lobe of liver; ; facial motor nucleus; ; supraoptic nucleus; ; jejunum; ; aortic valve; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; molybdopterin synthase activity; nucleotide binding;
Cellular component	molybdopterin synthase complex; cytosol; nucleus; cytoplasm; nuclear speck;
Biological process	Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4338
	17434
	ENSG00000164172
	ENSMUSG00000015536
	O96007; O96033
	Q9Z223; Q9Z224
	NM_176806; NM_004531
	NM_001113374; NM_001113375; NM_013826
	NP_004522; NP_789776; NP_789776.1
	NP_001106845; NP_001106846; NP_038854
	Wikidata
View/Edit Human	View/Edit Mouse

Molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B are a pair of proteins that in humans are encoded from the same MOCS2 gene.^[5]^[6]^[7] These two proteins dimerize to form molybdopterin synthase.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164172 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015536 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reiss J, Dorche C, Stallmeyer B, Mendel RR, Cohen N, Zabot MT (March 1999). "Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B". American Journal of Human Genetics. 64 (3): 706–11. doi:10.1086/302296. PMC 1377787. PMID 10053004.
^ Sloan J, Kinghorn JR, Unkles SE (February 1999). "The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames". Nucleic Acids Research. 27 (3): 854–8. doi:10.1093/nar/27.3.854. PMC 148257. PMID 9889283.
^ EntrezGene 4338: MOCS2 molybdenum cofactor synthesis 2

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164172 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015536 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10053004-5] Reiss J, Dorche C, Stallmeyer B, Mendel RR, Cohen N, Zabot MT (March 1999). "Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B". American Journal of Human Genetics. 64 (3): 706–11. doi:10.1086/302296. PMC 1377787. PMID 10053004.

[pmid9889283-6] Sloan J, Kinghorn JR, Unkles SE (February 1999). "The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames". Nucleic Acids Research. 27 (3): 854–8. doi:10.1093/nar/27.3.854. PMC 148257. PMID 9889283.

[entrez-7] EntrezGene 4338: MOCS2 molybdenum cofactor synthesis 2

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