MOV10

MOV10
Identifiers
Aliases	MOV10, fSAP113, gb110, Mov10 RISC complex RNA helicase
External IDs	OMIM: 610742; MGI: 97054; HomoloGene: 10365; GeneCards: MOV10; OMA:MOV10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	112,700,756 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	104,725,879 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right uterine tube; ; anterior pituitary; ; right lobe of liver; ; granulocyte; ; skin of arm; ; skin of abdomen; ; mucosa of transverse colon; ; right adrenal cortex;
	Top expressed in
	blastocyst; ; granulocyte; ; tail of embryo; ; yolk sac; ; genital tubercle; ; gallbladder; ; duodenum; ; ankle joint; ; zygote; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; helicase activity; protein binding; hydrolase activity; ATP binding; RNA binding; 5'-3' RNA helicase activity;
Cellular component	cytoplasm; P-body; extracellular space; cytosol; nucleus; cytoplasmic stress granule; cytoplasmic ribonucleoprotein granule; P granule;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; mRNA destabilization-mediated gene silencing by miRNA; gene silencing; Wnt signaling pathway, calcium modulating pathway; gene silencing by miRNA; regulation of megakaryocyte differentiation; negative regulation of transposition, RNA-mediated; positive regulation of gene expression; negative regulation of gene expression; RNA interference; positive regulation of mRNA catabolic process; 3'-UTR-mediated mRNA destabilization; regulation of neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologs
	4343
	17454
	ENSG00000155363
	ENSMUSG00000002227
	Q9HCE1
	P23249
NM_001130079; NM_001286072; NM_020963; NM_001321324; NM_001369507;
	NM_001389562; NM_001389563
	NM_001163440; NM_001163441; NM_008619
	NP_001123551; NP_001273001; NP_001308253; NP_066014; NP_001356436
	NP_001156912; NP_001156913; NP_032645
	Wikidata
View/Edit Human	View/Edit Mouse

Putative helicase MOV-10 is an enzyme that in humans is encoded by the MOV10 gene.^[5] Stability of MOV10 protein is controlled via DCAF12 ubiquitin ligase.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155363 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002227 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse)".
^ Lidak, Tomas (20 May 2021). "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation". Int J Mol Sci. 22 (10): 5394. doi:10.3390/ijms22105394. PMC 8161014. PMID 34065512.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155363 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002227 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse)".

[6] Lidak, Tomas (20 May 2021). "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation". Int J Mol Sci. 22 (10): 5394. doi:10.3390/ijms22105394. PMC 8161014. PMID 34065512.

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