The Medical Research Council (MRC) Laboratory of Medical Sciences (LMS) (formerly MRC Clinical Sciences Centre, and then the MRC London Institute of Medical Sciences) is a biomedical research institute based in West London, UK. Research at the institute focuses on the understanding of the molecular and physiological basis of health and disease. The LMS was established in 1994 and receives core funding from the Medical Research Council like the Laboratory of Molecular Biology at Cambridge University. The institute is hosted by Imperial College London at the Hammersmith Hospital.,[1][2] and is part of the Institute of Clinical Sciences (ICS), a department in the Imperial College London, Faculty of Medicine. It was led by Amanda Fisher from 2008-2021. In January 2023 the leadership was taken up by new director Wiebke Arlt.