MRGPRX2

MRGPRX2
Identifiers
Aliases	MRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2
External IDs	OMIM: 607228; MGI: 3588270; HomoloGene: 24986; GeneCards: MRGPRX2; OMA:MRGPRX2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	19,060,717 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	48,149,069 bp
RNA expression pattern
	Top expressed in
	testicle; ; skin of abdomen; ; skin of leg; ; subcutaneous adipose tissue; ; rectum; ; urinary bladder; ; fundus; ; vagina; ; gastric mucosa; ; smooth muscle tissue;
	Top expressed in
	muscle of thigh; ; zone of skin; ; quadriceps femoris muscle; ; lip; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide binding; signal transducer activity; mast cell secretagogue receptor activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane; mast cell granule; integral component of plasma membrane;
Biological process	sleep; positive regulation of cytokinesis; mast cell activation; G protein-coupled receptor signaling pathway; signal transduction; sensory perception of pain; mast cell degranulation;
	Sources:Amigo / QuickGO
Orthologs
	117194
	243978
	ENSG00000183695
	ENSMUSG00000074109
	Q96LB1
	Q3UG50
	NM_001303615; NM_054030
	NM_001034868
	NP_001290544; NP_473371
	NP_001030040
	Wikidata
View/Edit Human	View/Edit Mouse

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.^[5]^[6] It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.^[7]

Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome), icatibant, leuprolide, and morphine.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183695 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074109 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (September 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
^ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".
^ ^a ^b Akin C, Elhosni M, Khokar DS (2023). "Mast Cells and Mast Cell disorders". In Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck J (eds.). Clinical immunology: principles and practice. Elsevier. p. 563. ISBN 978-0-7020-8165-1.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183695 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074109 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11551509-5] Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (September 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.

[entrez-6] "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".

[Rich-7] Akin C, Elhosni M, Khokar DS (2023). "Mast Cells and Mast Cell disorders". In Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck J (eds.). Clinical immunology: principles and practice. Elsevier. p. 563. ISBN 978-0-7020-8165-1.

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