MT-CYB

CYTB
Identifiers
Aliases	CYTB, MTCYB, MT-CYB, cytochrome b
External IDs	OMIM: 516020; MGI: 102501; HomoloGene: 5013; GeneCards: CYTB; OMA:CYTB - orthologs
Gene location (Human) Chr. Mitochondrial DNA (human)[1] Band n/a Start 14,747 bp[1] End 15,887 bp[1]
Gene location (Mouse) Chr. Mitochondrial DNA (mouse)[2] Band n/a Start 14,145 bp[2] End 15,288 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastric mucosa right lobe of thyroid gland left ventricle putamen caudate nucleus left uterine tube nucleus accumbens subcutaneous adipose tissue right adrenal cortex Top expressed in neural layer of retina hypothalamus striatum of neuraxis adrenal gland dentate gyrus of hippocampal formation granule cell right kidney primary visual cortex superior frontal gyrus cerebellum cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquinol-cytochrome-c reductase activity protein-containing complex binding metal ion binding electron transfer activity oxidoreductase activity heme binding Cellular component mitochondrial respiratory chain complex III integral component of membrane respiratory chain complex III membrane mitochondrion mitochondrial inner membrane respirasome integral component of mitochondrial inner membrane protein-containing complex Biological process response to hypoxia response to glucagon response to cadmium ion response to organic cyclic compound response to nutrient response to copper ion response to hyperoxia hyperosmotic salinity response response to heat response to calcium ion animal organ regeneration response to organonitrogen compound response to hormone response to mercury ion response to ethanol response to toxic substance response to cobalamin proton transmembrane transport respiratory electron transport chain mitochondrial electron transport, ubiquinol to cytochrome c electron transport coupled proton transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4519 17711 Ensembl ENSG00000198727 ENSMUSG00000064370 UniProt P00156 P00158 RefSeq (mRNA) n/a n/a RefSeq (protein) n/a NP_904340 Location (UCSC) Chr M: 0.01 – 0.02 Mb Chr M: 0.01 – 0.02 Mb PubMed search [3] [4]
Wikidata
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Cytochrome b is a protein that in humans is encoded by the MT-CYB gene.^[5] Its gene product is a subunit of the respiratory chain protein ubiquinol–cytochrome c reductase (UQCR, complex III or cytochrome bc₁ complex), which consists of the products of one mitochondrially encoded gene, MT-CYB (mitochondrial cytochrome b), and ten nuclear genes—UQCRC1, UQCRC2, CYC1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c₁ Hinge protein), Rieske protein presequence, "cyt c₁ associated protein", and Rieske-associated protein.