MYB (gene)

MYB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GUU, 1GV2, 1GV5, 1GVD, 1H88, 1H89, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 1SB0, 2AGH
Identifiers
Aliases	MYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
External IDs	OMIM: 189990; MGI: 97249; HomoloGene: 31311; GeneCards: MYB; OMA:MYB - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	135,219,173 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	21,036,883 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; bronchial epithelial cell; ; trabecular bone; ; bone marrow; ; thymus; ; rectum; ; buccal mucosa cell; ; bone marrow cells; ; mucosa of transverse colon; ; right uterine tube;
	Top expressed in
	thymus; ; tibiofemoral joint; ; left colon; ; fetal liver hematopoietic progenitor cell; ; crypt of lieberkuhn of small intestine; ; Paneth cell; ; hair follicle; ; femur; ; body of femur; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear matrix; nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; chromatin remodeling; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; positive regulation of histone H3-K4 methylation; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of histone H3-K9 methylation; positive regulation of T-helper cell differentiation; transcription by RNA polymerase II; mitotic cell cycle; response to hypoxia; positive regulation of collagen biosynthetic process; positive regulation of neuron apoptotic process; positive regulation of smooth muscle cell proliferation; positive regulation of glial cell proliferation; cellular response to hydrogen peroxide; cellular response to retinoic acid; positive regulation of transforming growth factor beta production; positive regulation of neuron death; positive regulation of hepatic stellate cell proliferation; positive regulation of hepatic stellate cell activation; positive regulation of testosterone secretion; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4602
	17863
	ENSG00000118513
	ENSMUSG00000019982
	P10242; Q708E1
	P06876
NM_001130172; NM_001130173; NM_001161656; NM_001161657; NM_001161658;
	NM_001161659; NM_001161660; NM_005375
	NM_001198914; NM_010848; NM_033597
NP_001123644; NP_001123645; NP_001155128; NP_001155129; NP_001155130;
	NP_001155131; NP_001155132; NP_005366
	NP_001185843; NP_034978
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Myb-like DNA-binding domain
Myb-like DNA-binding domain
Identifiers
Symbol	Myb_DNA-binding
Pfam	PF00249
InterPro	IPR001005
PROSITE	PDOC00037
CATH	1irz
SCOP2	1irz / SCOPe / SUPFAM
CDD	cd00167
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper.^[5]^[6] Members of the extended SANT/Myb family also include the SANT domain and other similar all-helical homeobox-like domains.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118513 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019982 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys Res Commun. 360 (2): 433–6. doi:10.1016/j.bbrc.2007.06.078. PMID 17599807.
^ "Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118513 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019982 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17599807-5] Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys Res Commun. 360 (2): 433–6. doi:10.1016/j.bbrc.2007.06.078. PMID 17599807.

[entrez-6] "Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)".

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