MYCL

MYCL
Identifiers
Aliases	MYCL, LMYC, MYCL1, bHLHe38, L-Myc, v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, MYCL proto-oncogene, bHLH transcription factor
External IDs	OMIM: 164850; MGI: 96799; HomoloGene: 3921; GeneCards: MYCL; OMA:MYCL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	39,902,256 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	122,896,278 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of leg; ; epithelium of esophagus; ; skin of abdomen; ; skin of thigh; ; granulocyte; ; body of pancreas; ; mucosa of urinary bladder; ; gonad; ; gums;
	Top expressed in
	transitional epithelium of urinary bladder; ; corneal stroma; ; hair follicle; ; ventricular zone; ; ganglionic eminence; ; tail of embryo; ; white matter of cerebellum; ; genital tubercle; ; lip; ; medial ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein dimerization activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; regulation of inner ear auditory receptor cell differentiation; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4610
	16918
	ENSG00000116990
	ENSMUSG00000028654
	P12524
	P10166
	NM_005376; NM_001033081; NM_001033082
	NM_008506; NM_001303121
	NP_001028253; NP_001028254; NP_005367
	NP_001290050; NP_032532
	Wikidata
View/Edit Human	View/Edit Mouse

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.^[5]^[6]

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116990 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028654 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772.
^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".
^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. doi:10.1002/j.1460-2075.1989.tb03573.x. PMC 401025. PMID 2548855.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116990 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028654 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978772-5] Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772.

[entrez-6] "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".

[7] Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. doi:10.1002/j.1460-2075.1989.tb03573.x. PMC 401025. PMID 2548855.

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