MYD88

MYD88
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JS7, 2Z5V, 3MOP, 4DOM, 4EO7
Identifiers
Aliases	MYD88, MYD88D, myeloid differentiation primary response 88, innate immune signal transduction adaptor, MYD88 innate immune signal transduction adaptor, IMD68
External IDs	OMIM: 602170; MGI: 108005; HomoloGene: 1849; GeneCards: MYD88; OMA:MYD88 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,138,478 bp[1] End 38,143,022 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F3|9 71.33 cM Start 119,165,000 bp[2] End 119,170,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in white blood cell mononuclear cell monocyte granulocyte blood gingival epithelium mucosa of ileum periodontal fiber nasal epithelium palpebral conjunctiva Top expressed in granulocyte stroma of bone marrow right lung lobe lip ankle joint uterus esophagus tibiofemoral joint blood duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function death receptor binding protein binding TIR domain binding identical protein binding protein self-association Toll-like receptor binding Cellular component cytosol plasma membrane endosome membrane cytoplasm nucleus Biological process response to interleukin-1 immune system process negative regulation of apoptotic process MyD88-dependent toll-like receptor signaling pathway toll-like receptor signaling pathway cell surface receptor signaling pathway cellular response to mechanical stimulus regulation of inflammatory response positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling toll-like receptor 9 signaling pathway positive regulation of interleukin-17 production inflammatory response 3'-UTR-mediated mRNA stabilization positive regulation of type I interferon production positive regulation of interleukin-23 production signal transduction defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity apoptotic process innate immune response type I interferon signaling pathway positive regulation of gene expression positive regulation of interleukin-8 production defense response to bacterium interleukin-1-mediated signaling pathway cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response phagocytosis Toll signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4615 17874 Ensembl ENSG00000172936 ENSMUSG00000032508 UniProt Q99836 P22366 RefSeq (mRNA) NM_001172566 NM_001172567 NM_001172568 NM_001172569 NM_002468 NM_001365876 NM_001365877 NM_001374787 NM_001374788 NM_010851 RefSeq (protein) NP_001166037 NP_001166038 NP_001166039 NP_001166040 NP_002459 NP_001352805 NP_001352806 NP_001361716 NP_001361717 NP_034981 Location (UCSC) Chr 3: 38.14 – 38.14 Mb Chr 9: 119.17 – 119.17 Mb PubMed search [3] [4]
Wikidata
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Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene.^[5][6] originally discovered in the laboratory of Dan A. Liebermann (Lord et al. Oncogene 1990) as a Myeloid differentiation primary response gene.