MYOM1

MYOM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R15, 2Y23, 2Y25, 3RBS
Identifiers
Aliases	MYOM1, SKELEMIN, myomesin 1
External IDs	OMIM: 603508; MGI: 1341430; HomoloGene: 31196; GeneCards: MYOM1; OMA:MYOM1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.31 Start 3,066,807 bp[1] End 3,219,968 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E1.3 Start 71,309,628 bp[2] End 71,433,851 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii glutes apex of heart gastrocnemius muscle triceps brachii muscle left ventricle vastus lateralis muscle right auricle Top expressed in triceps brachii muscle temporal muscle muscle of thigh sternocleidomastoid muscle digastric muscle triceps surae gastrocnemius muscle medial head of gastrocnemius muscle vastus lateralis muscle tibialis anterior muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of muscle protein binding protein homodimerization activity identical protein binding actin filament binding muscle alpha-actinin binding structural molecule activity conferring elasticity kinase binding Cellular component cytoplasm myosin filament sarcomere striated muscle myosin thick filament Z discdkac M band striated muscle thin filament Biological process muscle contraction extraocular skeletal muscle development striated muscle contraction actin filament organization sarcomere organization striated muscle myosin thick filament assembly positive regulation of gene expression protein kinase A signaling positive regulation of protein secretion skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly cardiac myofibril assembly cardiac muscle tissue morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8736 17929 Ensembl ENSG00000101605 ENSMUSG00000024049 UniProt P52179 Q62234 RefSeq (mRNA) NM_003803 NM_019856 NM_001083934 NM_010867 RefSeq (protein) NP_003794 NP_062830 NP_001077403 NP_034997 Location (UCSC) Chr 18: 3.07 – 3.22 Mb Chr 17: 71.31 – 71.43 Mb PubMed search [3] [4]
Wikidata
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Myomesin-1 is a protein that in humans is encoded by the MYOM1 gene.^[5][6] Myomesin-1 is expressed in muscle cells and functions to stabilize the three-dimensional conformation of the thick filament. Embryonic forms of Myomesin-1 have been detected in dilated cardiomyopathy.