MYT1

MYT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JX1, 2JYD, 2MF8
Identifiers
Aliases	MYT1, C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A, ZC2H2C1, myelin transcription factor 1
External IDs	OMIM: 600379; MGI: 1100535; HomoloGene: 3332; GeneCards: MYT1; OMA:MYT1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	64,242,253 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,827,797 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; hypothalamus; ; amygdala; ; substantia nigra; ; nucleus accumbens; ; testicle; ; islet of Langerhans;
	Top expressed in
	lumbar spinal ganglion; ; Rostral migratory stream; ; ganglionic eminence; ; neural layer of retina; ; ventricular zone; ; medial ganglionic eminence; ; zygote; ; autonomic nervous system; ; superior cervical ganglion; ; trigeminal ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; zinc ion binding; metal ion binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	multicellular organism development; nervous system development; regulation of transcription, DNA-templated; cell differentiation; transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4661
	17932
	ENSG00000196132
	ENSMUSG00000010505
	Q01538
	Q8CFC2
	NM_004535
	NM_001171615; NM_001171616; NM_001171680; NM_008665
	NP_004526
	NP_001165086; NP_001165087; NP_001165151; NP_032691
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196132 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010505 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.
^ Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
^ "Entrez Gene: MYT1 myelin transcription factor 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196132 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010505 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1280325-5] Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.

[pmid9268380-6] Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.

[entrez-7] "Entrez Gene: MYT1 myelin transcription factor 1".

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