Macrophage inflammatory protein

chemokine (C-C motif) ligand 3
Human Mip-1α dimer D26A mutant. PDB 1b53.[1] Disulfide bonds highlighted.
Identifiers
SymbolCCL3
Alt. symbolsSCYA3, MIP-1α
NCBI gene6348
HGNC10627
OMIM182283
PDB1B50 More structures
RefSeqNM_002983
UniProtP10147
Other data
LocusChr. 17 q12
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StructuresSwiss-model
DomainsInterPro
chemokine (C-C motif) ligand 4
Human Mip-1β dimer. PDB 1hum.[2] Disulfide bonds highlighted.
Identifiers
SymbolCCL4
Alt. symbolsSCYA4, MIP-1β, LAG1
NCBI gene6351
HGNC10630
OMIM182284
PDB1HUM More structures
RefSeqNM_002984
UniProtP13236
Other data
LocusChr. 17 q21-q23
Search for
StructuresSwiss-model
DomainsInterPro

Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β, renamed CCL3 and CCL4 respectively, since 2000.[3] However, other names are sometimes encountered in older literature, such as LD78α, AT 464.1 and GOS19-1 for human CCL3 and AT 744, Act-2, LAG-1, HC21 and G-26 for human CCL4.[4] Other macrophage inflammatory proteins include MIP-2, MIP-3 and MIP-5.

  1. ^ Czaplewski LG, McKeating J, Craven CJ, Higgins LD, Appay V, Brown A, et al. (June 1999). "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants". The Journal of Biological Chemistry. 274 (23): 16077–84. doi:10.1074/jbc.274.23.16077. PMID 10347159.
  2. ^ Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, Leonard WJ, et al. (March 1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science. 263 (5154): 1762–7. Bibcode:1994Sci...263.1762L. doi:10.1126/science.8134838. PMID 8134838.
  3. ^ Zlotnik A, Yoshie O (February 2000). "Chemokines: a new classification system and their role in immunity". Immunity. 12 (2): 121–7. doi:10.1016/S1074-7613(00)80165-X. PMID 10714678.
  4. ^ Menten P, Wuyts A, Van Damme J (December 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.