| Major intrinsic protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of a glycerol-conducting channel.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | MIP | ||||||||
| Pfam | PF00230 | ||||||||
| InterPro | IPR000425 | ||||||||
| PROSITE | PDOC00193 | ||||||||
| SCOP2 | 1fx8 / SCOPe / SUPFAM | ||||||||
| TCDB | 1.A.8 | ||||||||
| OPM superfamily | 7 | ||||||||
| OPM protein | 1z98 | ||||||||
| CDD | cd00333 | ||||||||
| |||||||||
Major intrinsic proteins comprise a large superfamily of transmembrane protein channels that are grouped together on the basis of homology. The MIP superfamily includes three subfamilies: aquaporins, aquaglyceroporins and S-aquaporins.[2]
- The aquaporins (AQPs) are water selective.
- The aquaglyceroporins are permeable to water, but also to other small uncharged molecules such as glycerol.
- The third subfamily, with little conserved amino acid sequences around the NPA boxes, include 'superaquaporins' (S-aquaporins).
The phylogeny of insect MIP family channels has been published.[3][4][5]
- ^ Fu D, Libson A, Miercke LJ, et al. (October 2000). "Structure of a glycerol-conducting channel and the basis for its selectivity". Science. 290 (5491): 481–6. Bibcode:2000Sci...290..481F. doi:10.1126/science.290.5491.481. PMID 11039922.
- ^ Benga, Gheorghe (2012-12-01). "On the definition, nomenclature and classification of water channel proteins (aquaporins and relatives)". Molecular Aspects of Medicine. 33 (5–6): 514–517. doi:10.1016/j.mam.2012.04.003. ISSN 1872-9452. PMID 22542572.
- ^ Reizer J, Reizer A, Saier Jr MH (1993). "The MIP family of integral membrane channel proteins: sequence comparisons, evolutionary relationships, reconstructed pathway of evolution, and proposed functional differentiation of the two repeated halves of the proteins". Crit. Rev. Biochem. Mol. Biol. 28 (3): 235–257. doi:10.3109/10409239309086796. PMID 8325040.
- ^ Pao GM, Johnson KD, Chrispeels MJ, Sweet G, Sandal NN, Wu LF, Saier Jr MH, Hofte H (1991). "Evolution of the MIP family of integral membrane transport proteins". Mol. Microbiol. 5 (1): 33–37. doi:10.1111/j.1365-2958.1991.tb01823.x. PMID 2014003. S2CID 8963595.
- ^ Finn, Roderick Nigel; Chauvigné, François; Stavang, Jon Anders; Belles, Xavier; Cerdà, Joan (2015-01-01). "Insect glycerol transporters evolved by functional co-option and gene replacement". Nature Communications. 6: 7814. Bibcode:2015NatCo...6.7814F. doi:10.1038/ncomms8814. ISSN 2041-1723. PMC 4518291. PMID 26183829.