Mamia IV Gurieli (Georgian: მამია IV გურიელი) (died 1778 or 1784), of the western Georgian House of Gurieli, was Prince of Guria from 1726 to 1756 and again from 1758 to 1765 and from 1771 to 1776. Intermissions of his rule was the result of Mamia's rivalry with his younger brother, Giorgi V Gurieli, and complex political situation in the region, including the Ottoman encroachments and efforts by the kings of Imereti to bring western Georgian polities under their supreme authority.