Marasmus

Marasmus
Photo from 1972 of an emaciated child in India with marasmus
SpecialtyCritical care medicine
CausesStarvation, malnutrition, cachexia

Marasmus is a form of severe malnutrition characterized by energy deficiency. It can occur in anyone with severe malnutrition but usually occurs in children. Body weight is reduced to less than 62% of the normal (expected) body weight for the age.[1] Marasmus occurrence increases prior to age 1, whereas kwashiorkor occurrence increases after 18 months. It can be distinguished from kwashiorkor in that kwashiorkor is protein deficiency with adequate energy intake whereas marasmus is inadequate energy intake in all forms, including protein. This clear-cut separation of marasmus and kwashiorkor is however not always clinically evident as kwashiorkor is often seen in a context of insufficient caloric intake, and mixed clinical pictures, called marasmic kwashiorkor, are possible. Protein wasting in kwashiorkor generally leads to edema and ascites, while muscular wasting and loss of subcutaneous fat are the main clinical signs of marasmus, which makes the ribs and joints protrude.[2]

The prognosis is better than it is for kwashiorkor.[3] Marasmus is the form of malnutrition most highly associated with HIV, developing in the last stages of pediatric AIDS, and the prognosis for children with co-morbid marasmus and HIV is very poor.[4]

The word "marasmus" comes from the Greek μαρασμός marasmos ("withering").

  1. ^ Appleton & Vanbergen, Metabolism and Nutrition, Medicine Crash Course 4th ed. Moseby (London: 2013) p.130
  2. ^ Müller, Olaf; Krawinkel, Michael (2005-08-02). "Malnutrition and health in developing countries". CMAJ: Canadian Medical Association Journal. 173 (3): 279–286. doi:10.1503/cmaj.050342. ISSN 0820-3946. PMC 1180662. PMID 16076825.
  3. ^ Badaloo AV, Forrester T, Reid M, Jahoor F (June 2006). "Lipid kinetic differences between children with kwashiorkor and those with marasmus". Am. J. Clin. Nutr. 83 (6): 1283–8. doi:10.1093/ajcn/83.6.1283. PMID 16762938.
  4. ^ Prazuck, Thierry; Tall, François; Macro, Boubacar; Rochereau, Anne; Traore, Antoinette; Sanou, Théophille; Malkin, Jean-Elie; Apaire-Marchais, Véronique; Masson, Damienne; Dublanchet, Alain; Lafaix, Christian (January 1993). "HIV infection and severe malnutrition". AIDS. 7 (1): 103–108. doi:10.1097/00002030-199301000-00016. ISSN 0269-9370. S2CID 12330805.