| Margherita Gonzaga | |
|---|---|
 | |
| Duchess consort of Lorraine | |
| Tenure | 14 May 1608 – 31 July 1624 |
| Born | 2 October 1591 Mantua |
| Died | 7 February 1632 (aged 40) Nancy |
| Spouse | |
| Issue | |
| House | Gonzaga |
| Father | Vincenzo Gonzaga, Duke of Mantua |
| Mother | Eleonora de' Medici |
Margherita Gonzaga (2 October 1591 – 7 February 1632) was Duchess of Lorraine from 1606 until 1624 by marriage to Henry II, Duke of Lorraine. She was an agent of Pro-French and anti-Protestant policy in Lorraine, and is most known for her support of her daughter Nicole's right to the Duchy of Lorraine. She also claimed her right to the Duchy of Montferrat during the Mantuan war of succession.