Marginal-zone B cell

Histology of a normal lymphoid follicle, with marginal zone annotated at bottom.

Marginal-zone B cells (MZ B cells) are noncirculating mature B cells that in humans segregate anatomically into the marginal zone (MZ) of the spleen[1] and certain other types of lymphoid tissue.[2] The MZ B cells within this region typically express low-affinity polyreactive B-cell receptors (BCR), high levels of IgM, Toll-like receptors (TLRs), CD21, CD1, CD9, CD27 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells.[2][3]

MZ B cells are innate-like B cells specialized to mount rapid T-independent, but also T-dependent responses against blood-borne pathogens.[4] They are also known to be the main producers of IgM antibodies in humans.[5]

  1. ^ Martin F, Kearney JF (2002). "Marginal-zone B cells". Nat Rev Immunol. 2 (5): 323–335. doi:10.1038/nri799. PMID 12033738. S2CID 22573840.
  2. ^ a b Cerutti A, Cols M, Puga I (February 2013). "Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes". Nature Reviews. Immunology. 13 (2): 118–32. doi:10.1038/nri3383. PMC 3652659. PMID 23348416.
  3. ^ Won, Woong-Jai; Kearney, John F. (2002-06-01). "CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice". Journal of Immunology. 168 (11): 5605–5611. doi:10.4049/jimmunol.168.11.5605. ISSN 0022-1767. PMID 12023357.
  4. ^ Turner, Vivian M.; Mabbott, Neil A. (July 2017). "Ageing adversely affects the migration and function of marginal zone B cells". Immunology. 151 (3): 349–362. doi:10.1111/imm.12737. ISSN 1365-2567. PMC 5461100. PMID 28369800.
  5. ^ Cite error: The named reference :3 was invoked but never defined (see the help page).