| Maria of Antioch | |
|---|---|
 Manuscript miniature of Empress Maria (Vatican Library) | |
| Byzantine Empress consort | |
| Tenure | 24 December 1161 - 24 September 1180 |
| Born | 1145 Antioch (now Antakya, Hatay, Turkey) |
| Died | 1182 (aged 36–37) |
| Spouse | Manuel I Komnenos |
| Issue | Alexios II Komnenos |
| House | House of Poitiers |
| Father | Raymond of Poitiers |
| Mother | Constance of Antioch |
Maria of Antioch (Greek: Μαρία; 1145–1182) was a Byzantine empress by marriage to Byzantine Emperor Manuel I Komnenos, and regent during the minority of her son porphyrogennetos Alexios II Komnenos from 1180 until 1182.