Markovnikov's rule

Markovnikov's rule is illustrated by the reaction of propene with hydrobromic acid

In organic chemistry, Markovnikov's rule or Markownikoff's rule describes the outcome of some addition reactions. The rule was formulated by Russian chemist Vladimir Markovnikov in 1870.[1][2][3]

  1. ^ W. Markownikoff (1870). "Ueber die Abhängigkeit der verschiedenen Vertretbarkeit des Radical wasserstoffs in den isomeren Buttersäuren" [On the dependence of the different substitutions of the radical hydrogen in the isomeric butyric acids]. Annalen der Chemie. 153 (1): 228–259. doi:10.1002/jlac.18701530204.
  2. ^ Hughes, Peter (2006). "Was Markovnikov's Rule an Inspired Guess?". Journal of Chemical Education. 83 (8): 1152. Bibcode:2006JChEd..83.1152H. doi:10.1021/ed083p1152.
  3. ^ Lewis, David E. (2021). "The Logic Behind Markovnikov's Rule: Was It an Inspired Guess? …No!". Angewandte Chemie International Edition. 60 (9): 4412–4421. doi:10.1002/anie.202008228. S2CID 230570680.