Mary Osborn (disambiguation)

Mary Osborn or Osborne may refer to:

• Mary Osborn (born 1940), English cell biologist
• Mary Jane Osborn (1927–2019), American biochemist and molecular biologist
• Mary Osborne (1921–1992), American jazz guitarist and guitar manufacturer
• Mary Pope Osborne (born 1949), American author
• Mary Osborne, Duchess of Leeds (1723–1764), noblewoman