| Massive perivillous fibrin deposition | |
|---|---|
| Other names | MPFD, MFD |
| Specialty | Obstetrics, pathology |
| Symptoms | none |
| Causes | unknown, may be autoimmune |
| Risk factors | previous MPFD |
| Diagnostic method | histology of the placenta |
| Treatment | none |
| Prognosis | 33% premature birth, 31% neonatal death |
| Frequency | 0.028% of all pregnancies, 18-50% recurrence in those affected |
Massive perivillous fibrin deposition (MPFD, or MFD) refers to excessive deposition of fibrous tissue around the chorionic villi of the placenta. It causes reduced growth of the foetus, and leads to miscarriage in nearly 1 in 3 pregnancies affected. There are typically no symptoms, and it is rarely detected before birth. The cause is unknown, but may be autoimmune. Diagnosis is based on the histology (cell appearance) of the placenta. There are currently no known treatments. MPFD is very rare, but recurrence is around 18% in those affected.