The matchbox sign, also referred to as the Ziploc bag sign or the specimen sign, is a psychiatric medical sign in which a patient arrives at a doctor's office with items extracted from the skin; these items are intended to serve as proof of a parasitic infestation, and are typically stored in a small container such as a matchbox.[1][2] 50–80% of patients with delusional parasitosis present with this sign.[3]
People with delusional parasitosis can damage their skin by attempting to remove imaginary parasites. These items may include scabs and skin particles, dust and dirt, and plant or animal fibers, and may be accompanied by photographs.[4] Laboratory analysis fails to find proof of parasitic infestation.[1]