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Matt Scott | |
|---|---|
 | |
| Citizenship | United States |
| Alma mater | Massachusetts Institute of Technology |
| Known for | Homeobox |
| Spouse | Margaret T. Fuller |
| Awards | Member of the National Academy of Sciences (1999)[1] |
| Scientific career | |
| Fields | Developmental biology |
| Institutions | Stanford University Carnegie Institution for Science University of Colorado Boulder Indiana University |
| Doctoral advisor | Mary Lou Pardue |
| Notable students | Sean B. Carroll Chris Q. Doe Eileen Furlong (postdoc)[2] |
| Website | profiles |
Matthew P. Scott is an American biologist who was the tenth president of the Carnegie Institution for Science.[3] While at Stanford University, Scott studied how embryonic and later development is governed by proteins that control gene activity and cell signaling processes.[4] [5] He co-[6] discovered homeobox genes in Drosophila melanogaster working with Amy J. Weiner at Indiana University.[7][8]
Among his laboratory's discoveries, he is recognized for the cloning of the patched gene family and demonstration that a human homolog PTCH1 is a key tumor suppressor gene for the Hedgehog signaling pathway as well as the causative gene for the nevoid basal cell carcinoma syndrome, or Gorlin syndrome.[9][10]
- ^ Cite error: The named reference
naswas invoked but never defined (see the help page). - ^ Furlong, Eileen E.M.; Profitt, David; Scott, Matthew P. (2001). "Automated sorting of live transgenic embryos". Nature Biotechnology. 19 (2): 153–156. doi:10.1038/84422. ISSN 1087-0156. PMID 11175730. S2CID 14228050.
- ^ "Matthew P. Scott's Profile | Stanford Profiles".
- ^ "Scott lab homepage at Stanford University". Archived from the original on 2008-12-04. Retrieved 2009-04-10.
- ^ "HHMI Scientist Bio: Matthew P. Scott, Ph.D." Retrieved 2009-04-10.
- ^ Amy J Weiner PhD Thesis Indiana University 1983
- ^ Scott, M. P. (1984). "Structural Relationships among Genes That Control Development: Sequence Homology between the Antennapedia, Ultrabithorax, and Fushi Tarazu Loci of Drosophila". Proceedings of the National Academy of Sciences. 81 (13): 4115–4119. Bibcode:1984PNAS...81.4115S. doi:10.1073/pnas.81.13.4115. PMC 345379. PMID 6330741.
- ^ Laughon, A.; Scott, M. P. (1984). "Sequence of a Drosophila segmentation gene: Protein structure homology with DNA-binding proteins". Nature. 310 (5972): 25–31. Bibcode:1984Natur.310...25L. doi:10.1038/310025a0. PMID 6330566. S2CID 4346123.
- ^ Hooper, J. E.; Scott, M. P. (1989). "The Drosophila patched gene encodes a putative membrane protein required for segmental patterning". Cell. 59 (4): 751–765. doi:10.1016/0092-8674(89)90021-4. PMID 2582494. S2CID 16246437.
- ^ Johnson, R. L.; Rothman, A. L.; Xie, J.; Goodrich, L. V.; Bare, J. W.; Bonifas, J. M.; Quinn, A. G.; Myers, R. M.; Cox, D. R.; Epstein, E. H. Jr.; Scott, M. P. (1996). "Human homolog of patched, a candidate gene for the basal cell nevus syndrome". Science. 272 (5268): 1668–1671. Bibcode:1996Sci...272.1668J. doi:10.1126/science.272.5268.1668. PMID 8658145. S2CID 9160210.