McCook is a surname. Notable people with the surname include:
- Katharine McCook (1889–1983), American art historian
- Brian Joseph McCook (born 1982), an American drag queen
- John McCook (born 1944), actor
- Tommy McCook (1927–1998), Jamaican saxophonist
- "The Fighting McCooks"
- Daniel McCook (1798–1863), killed in action during US Civil War
- Robert Latimer McCook (1827–1862), US general, killed during US Civil War, son of Daniel
- Alexander McDowell McCook (1831–1903), US general, son of Daniel
- John James McCook (lawyer) (1845–1911), soldier and lawyer, son Daniel
- Daniel McCook, Jr. (1834–1864) soldier, killed in action during US Civil War, son of Daniel
- Edwin S. McCook (1837–1873), Governor of Dakota Territory son of Dan
- John James McCook (1806–1865), served in Civil war, brother of Daniel
- Edward Moody McCook (1833–1909), soldier and governor, son of John
- Anson George McCook (1835–1917), politician, son of John
- Henry Christopher McCook (1837–1911), clergyman and naturalist, son of John
- John James McCook (professor) (1843–1927), clergyman and professor, son of John
- Roderick McCook (1839–1886), U.S. Naval officer, son of John