Melanin-concentrating hormone receptor 2

MCHR2
Identifiers
Aliases	MCHR2, GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT, melanin concentrating hormone receptor 2
External IDs	OMIM: 606111; HomoloGene: 50004; GeneCards: MCHR2; OMA:MCHR2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	99,994,247 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; Brodmann area 46; ; testicle; ; right frontal lobe; ; superior frontal gyrus; ; anterior cingulate cortex; ; primary visual cortex; ; postcentral gyrus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84539
	n/a
	ENSG00000152034
	n/a
	Q969V1
	n/a
	NM_032503; NM_001040179
	n/a
	NP_001035269; NP_115892
	n/a
	Wikidata
View/Edit Human

Melanin-concentrating hormone receptor 2 (MCH₂) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.^[3]^[4]^[5]

MCH₂ is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH₂ gene and its receptor product.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152034 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2".
^ Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M (May 2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.
^ Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI (June 2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152034 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2".

[pmid11355873-4] Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M (May 2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.

[pmid11274220-5] Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI (June 2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.

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